| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
In the recent years, we have an increasing trend non- tuberculous mycobacterial disease around the world. Anti-interferon gamma autoantibodies were often found in formerly healthy patients with disseminated NTM infections. In this study we intend to establish the measurement method of the autoantibodies in clinical specimens from patients.
We have developed the method to evaluate the neutralizing capacity to interferon-gamma of sera and to quantify the relative concentrations of the autoantibodies. Twenty-six antibody-positive cases were observed so far and also clarified their clinical characteristics. Antibody titer in response to the disease of non- tuberculous mycobacterial disease tend to increase or decrease , it is also useful as a marker to reflect the disease has been suggested .
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