Involvement of double-stranded RNA in the pathogenesis of prion disease
| Project/Area Number |
25461514
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Fukuoka University (2014-2015)
Nagasaki University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
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| Keywords | プリオン / dsRNA / 感染 |
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| Outline of Final Research Achievements |
Although the pathogenesis of prion disease has not been clarified fully, it is widely accepted that prion disease occurs through autocatalytic conformational conversion of the ubiquitous normal form of prion protein (PrPC) to PrPSc in a protein only manner. Meanwhile, activation of the innate immune system has been suggested to partially block the progression of prion disease. Furthermore, different prion strains can interfere with each other, and this is known as prion strain interference. The results suggest that cofactors, such as virus derived nucleic acids, involve in prion propagation. In this study, we demonstrated that double-stranded RNA innate immune responses play a key role in the pathogenesis of prion disease.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Characterisation of radioiodinated flavonoid derivatives for SPECT imaging of cerebral prion deposits.2015
Author(s)
Fuchigami T, Yamashita Y, Kawasaki M, Ogawa A, Haratake M, Atarashi R, Sano K, Nakagaki T, Ubagai K, Ono M, Yoshida S, Nishida N, Nakayama M.
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Journal Title
Sci Rep.
Volume: 5
Issue: 1
Pages: 18440-18440
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Rapid and Quantitative Assay of Amyloid-Seeding Activity in Human Brains Affected with Prion Diseases.2015
Author(s)
Takatsuki H, Satoh K, Sano K, Fuse T, Nakagaki T, Mori T, Ishibashi D, Mihara B, Takao M, Iwasaki Y, Yoshida M, Atarashi R, Nishida N.
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Journal Title
PLoS One
Volume: 10
Issue: 6
Pages: 0126930-0126930
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] FK506reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice.2013
Author(s)
Nakagaki T, Satoh K, Ishibashi D, Fuse T, Sano K, Kamatari YO, Kuwata K, Shigematsu K, Iwamaru Y, Takenouchi T, Kitani H, Nishida N, Atarashi R.
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Journal Title
Autophagy.
Volume: 9
Issue: 9
Pages: 1386-1394
DOI
NAID
Related Report
Peer Reviewed
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