An analysis of miRNA related host-microbial crosstalk
Project/Area Number |
25461520
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Infectious disease medicine
|
Research Institution | Keio University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
HOSHINO Yoshihiko 国立感染症研究所, ハンセン病研究センター 感染制御部, 室長 (20569694)
|
Research Collaborator |
NISHIMURA Tomoyasu 慶應義塾大学, 保健管理センター(日吉), 講師 (90348649)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 感染症 / miRNA |
Outline of Final Research Achievements |
To figure out the pathophysiology and find biomarkers reflecting disease activity and new therapeutic targets for Mycobacterium avium complex (MAC) pulmonary disease, which is an intractable chronic respiratory infection, we searched micro RNAs (miRNAs) associated with MAC pulmonary disease. By comparing the profile of serum miRNAs of the patients with that of healthy controls, we determined hsa-miR-346 as a miRNA associated with MAC pulmonary disease. We will evaluate whether this miRNA is a biomarker reflecting disease activity and perform further studies to figure out the pathophysiology of MAC pulmonary disease associated with hsa-miR-346 for novel treatment.
|
Report
(4 results)
Research Products
(117 results)
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[Journal Article] Disseminated Mycobacterium marinum Infection With a Destructive Nasal Lesion Mimicking Extranodal NK/T Cell Lymphoma: A Case Report.2016
Author(s)
ASAKURA T, ISHII M, KIKUCHI T, KAMEYAMA K, NAMKOONG H, NAKATA N, SUGITA K, TASAKA S, SHIMIZU T, HOSHINO Y, OKAMOTO S, BETSUYAKU T, HASEGAWA N.
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Takahashi S, Ishii M, Namkoong H, Hegab AE, Asami T, Yagi K, Sasaki M, Haraguchi M, Sato M, Kameyama N, Asakura T, Suzuki S, Tasaka S, Iwata S, Hasegawa N, Betsuyaku T.
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[Journal Article] Pulmonary nocardiosis caused by Nocardia cyriacigeorgica in patients with Mycobacterium avium complex lung disease: two case reports.2014
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[Journal Article] Pharmacokinetics of arbekacin in bronchial epithelial lining fluid of healthy volunteers.2014
Author(s)
Funatsu Y, Hasegawa N, Fujiwara H, Namkoong H, Asami T, Tasaka S, Kimizuka Y, Kamata H, Ishii M, Iketani O, Ogata H, Iwata S, Betsuyaku T
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[Journal Article] Modulation of murine macrophage TLR7/8-mediated cytokine expression by mesenchymal stem cell-conditioned medium2013
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110th International Conference of American Thoracic Society
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[Presentation] Health-Related Quality of Life in 235 Patients with Mycobacterium avium Complex Lung Disease in Japan2015
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T. Asakura, M.D., M. Ishii, M.D., Y. Funatsu, MD, K. Yagi, M.D., H. Namkoong, MD, S. Suzuki, M.D., T. Kamo, MD, T. Asami, MD, H. Fujiwara, MD, Y. Uwamino, MD, T. Nishimura, MD, PhD, S. Tasaka, MD, N. Hasegawa, MD, PhD, T. Betsuyaku, MD, PhD
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第55回日本呼吸器学会学術講演会
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Organizer
第55回日本呼吸器学会学術講演会
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東京国際フォーラム(東京都・千代田区)
Year and Date
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Organizer
第55回日本呼吸器学会学術講演会
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東京国際フォーラム(東京都・千代田区)
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Organizer
第55回日本呼吸器学会学術講演会
Place of Presentation
東京国際フォーラム(東京都・千代田区)
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2015-04-17
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第90回 日本結核病学会総会
Place of Presentation
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Year and Date
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第90回 日本結核病学会総会
Place of Presentation
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Author(s)
石井誠,朝倉祟徳,南宮湖,八木一馬,鈴木翔二,加茂徹郎,浅見貴弘,上蓑義典,藤原宏,西村知泰,田坂定智,別役智子,長谷川直樹
Organizer
第90回 日本結核病学会総会
Place of Presentation
長崎ブリックホール(長崎)
Year and Date
2015-03-28
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Author(s)
朝倉祟徳,石井誠,舩津洋平,八木一馬,南宮湖,鈴木翔二,浅見貴弘,加茂徹郎,上蓑義典,藤原宏,西村知泰,田坂定智,別役智子,長谷川直樹
Organizer
第90回 日本結核病学会総会
Place of Presentation
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第90回 日本結核病学会総会
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Organizer
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Author(s)
君塚善文,長谷川直樹, 星野仁彦, 石井誠, 西村知泰, 浅見貴弘, 田坂定智, 南宮湖, 藤原宏, 舩津洋平, 八木一馬, 阿部貴行, 前田伸司, 岩田敏, 別役智子
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第54回 日本呼吸器学会学術講演会
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Author(s)
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第54回 日本呼吸器学会学術講演会
Place of Presentation
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Place of Presentation
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[Book] 化学療法の領域2015
Author(s)
木津純子,大谷壽一,大野能之,福森史郎,辻康弘,森塚暁裕,北原隆志,藤村茂,堀野哲也,岩永直樹,栁原克紀,西圭史,松元一明,中村茂樹,宮﨑義継,坪井敬文,高島英造,生田弘史,矢島稔央,三輪明生,上島悦子,池谷 修, 長谷川 直樹
Total Pages
136
Publisher
医薬ジャーナル社
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[Book] 呼吸器内科2015
Author(s)
南宮 湖, 長谷川 直樹
Total Pages
6
Publisher
科学評論社
Related Report
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[Book] 診断と治療2014
Author(s)
西村 知泰, 森 正明, 長谷川 直樹
Total Pages
5
Publisher
医学書出版
Related Report
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