| Project/Area Number |
25461521
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Keio University |
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Principal Investigator |
Iwata Satoshi 慶應義塾大学, 医学部, 教授 (10129348)
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| Co-Investigator(Renkei-kenkyūsha) |
HASEGAWA Naoki 慶應義塾大学, 医学部, 教授 (20198724)
KATO Shingo 慶應義塾大学, 医学部, 専任講師 (10177446)
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| Research Collaborator |
FUJIWARA Hiroshi 慶應義塾大学, 医学部, 助教
SUDO Koji 慶應義塾大学, 医学部, 特任助教 (30566899)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | HIV / 薬剤定量 / 毛髪中薬剤定量 / ツルバダ / テノフォビル / エムトリシタビン / ＨＩＶ / 薬物定量 / 毛髪中薬物濃度 / テノホビル |
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| Outline of Final Research Achievements |
Measuring blood concentration of anti- HIV drugs is important for the optimization of the treatment and the prevention of the acquisition of drug-resistance. The drug concentration in hair is thought to reflect average blood concentration of the drug, and it is expected that we can estimate the long-term change of the blood levels of the drug by measuring drug concentrations of hairs from hair roots to hair tips.
This time we established the beads spall method for the drug extraction from the hair, and we measured the hair and blood concentrations of tenofovir (TFV) and emtricitabine (FTC), which are reverse transcriptase inhibitors, in HIV infected patients by using a liquid chromatography mass spectrometry. As a result, the possibilities to be able to estimate the long-term change of the blood levels of TFV and FTC by measuring the drug concentration of the hair were shown.
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