| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Histopathology of mouse lung infected by Cryptococcus gattii showed low inflammatory response, whereas that of mouse lung infected by Cryptococcus neoformans indicated Th1 type inflammatory response. Additionally, several virulence factors of C. neoformans, such as capsule size or melanin production, were determined on C. gattii strains in order to evaluate the relationship between virulence for mice and those virulence factor. Consequently, it seemed no relation between virulence for mice and virulence factors. On the other hand, therapeutic effect of interferon gamma (IFN-g) on cryptococcus infection mouse model was determined. Fungal burden in the lung of C. neoformans infected mouse had reduced in IFN-g therapy group comparing to control group in this study.
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