Evaluation of pathology, virulence factor of, and effective chemotherapy against cryptococcosis caused by highly virulent Cryptococcus gattii.
Project/Area Number |
25461526
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Infectious disease medicine
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Research Institution | Saitama Medical University (2014-2015) National Institute of Infectious Diseases (2013) |
Principal Investigator |
OHNO HIDEAKI 埼玉医科大学, 医学部, 教授 (20325640)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | クリプトコックス症 / 高病原性 / 感染病態 / 病原因子 / クリプトコックス |
Outline of Final Research Achievements |
Histopathology of mouse lung infected by Cryptococcus gattii showed low inflammatory response, whereas that of mouse lung infected by Cryptococcus neoformans indicated Th1 type inflammatory response. Additionally, several virulence factors of C. neoformans, such as capsule size or melanin production, were determined on C. gattii strains in order to evaluate the relationship between virulence for mice and those virulence factor. Consequently, it seemed no relation between virulence for mice and virulence factors. On the other hand, therapeutic effect of interferon gamma (IFN-g) on cryptococcus infection mouse model was determined. Fungal burden in the lung of C. neoformans infected mouse had reduced in IFN-g therapy group comparing to control group in this study.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Successful Treatment of <i>Cryptococcus laurentii</i> Peritonitis in a Patient on Peritoneal Dialysis2015
Author(s)
Asano M, Mizutani M, Nagahara Y, Inagaki K, Kariya T, Masamoto D, Urai M, Kaneko Y, Ohno H, Miyazaki Y, Mizuno M, Ito Y.
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Journal Title
Internal Medicine
Volume: 54
Issue: 8
Pages: 941-944
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access
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[Journal Article] Invasive pulmonary aspergillosis due to Aspergillus lentulus: Successful treatment of a liver transplant patient.2015
Author(s)
Yoshida H, Seki M, Umeyama T, Urai M, Kinjo Y, Nishi I, Toyokawa M, Kaneko Y, Ohno H, Miyazaki Y, Tomono K.
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Journal Title
J Infect Chemother
Volume: epub
Issue: 6
Pages: 479-481
DOI
Related Report
Peer Reviewed / Open Access
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