| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Initially, I have tired to find genetic abnormality in autism spectrum disorders by comprehensive analyses for whole genome. Although I have successively found a gene abnormality in the specific chromosome in some patients, the majority of patients did not show any specific abnormality in my gene sequence. For deeper understanding of the mechanisms of autism, I next analyzed electrophysiological functions in a model mouse of genetically confirmed autism spectrum disorder, UBE3A deficit mouse. I have illustrated that tonic inhibitory function is specifically decreased in the cortex or hippocampus, but not the thalamus in UBE3A deficit mouse. Because similar decrements have been recently shown in other autism models, the deficiency of tonic inhibition might be a common pathophysiology of autism spectrum disorders. On the others, my finding which shows the imbalance of inhibition among brain region can provoke a novel hypothesis for the mechanism in autism spectrum disorder.
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