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Cognitive neuroscience study of relation between cogniton and emotion, and decision-making in developmental disorders

Research Project

Project/Area Number 25461540
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionUniversity of Yamanashi

Principal Investigator

AIHARA Masao  山梨大学, 総合研究部, 教授 (30242639)

Research Collaborator KANEMURA Hideaki  
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords認知神経科学 / 前頭葉機能 / 意思決定 / 情動反応 / 瞳孔計 / 発達障害 / 長期報酬 / 認知機能 / 情動機能 / 瞳孔 / 光トポグラフィー / 実行機能
Outline of Final Research Achievements

In daily life, we perform repeated decision-making, considering several choices in uncertain circumstances. The pretofront cortex, which is center of cognitive/emotional neuronal network, is an important region for the ability to make decision. We hypothesize that autonomic emotional responses can affect decision-making.
The aim of our reseach was to clarify the involvement of the autonomic system during an executive functional task via developmental changes assessed using pupillometry. Subjects were 16 healthy children (7-14 years), 13 cildren with ADHD and 9 healthy adults. Pupil diameter was recorded using an eye mark recorder during cognitive shift (CS) in the Wisconsin card sorting test. The change of pupillary diameter was increased with CS in adults. Changes of pupillary diameter with CS in ADHD showed significantly lower than those in healthy children. Our study suggest that autonomic emotional response play an important role as a part of the process for decision-making.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (39 results)

All 2017 2016 2015 2014 2013 Other

All Journal Article (15 results) (of which Peer Reviewed: 14 results,  Acknowledgement Compliant: 8 results,  Open Access: 5 results) Presentation (17 results) (of which Invited: 12 results) Book (7 results)

  • [Journal Article] Developmental changes in autonomic emotional responses during an executive functional task: a pupillometric study during Wisconsin card sorting test.2017

    • Author(s)
      Ohyama T, Kaga Y, Goto Y, Aoyagi K, Ishii S, Kanemura H, Sugita K, Aihara M.
    • Journal Title

      Brain Dev

      Volume: 39 Issue: 3 Pages: 187-195

    • DOI

      10.1016/j.braindev.2016.10.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Disinhibition in children with ADHD: Changes in [oxy-Hb] on near-infrared spectorscopy during "rock, papaer, scissors" task2017

    • Author(s)
      Ishii S, Kaga Y, Tando T, Aoyagi K, Sano F, Kanemura H, Sugita K, Aihara M
    • Journal Title

      Brain Dev

      Volume: 39 Issue: 5 Pages: 395-402

    • DOI

      10.1016/j.braindev.2016.12.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Correlation between perceived stigma and EEG paroxysmal abnormality in childhood epilepsy.2015

    • Author(s)
      Kanemura H, Sano F, Ohyama T, Sugita K, Aihara M.
    • Journal Title

      Epilepsy Behav

      Volume: 52 Pages: 44-48

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Risk factors for seizure recurrence in children after first unprovoked seizure2015

    • Author(s)
      Mizorogi S, Kanemura H, Sano F, Sugita K, Aihara M.
    • Journal Title

      Pediatr Int

      Volume: 57 Pages: 665-669

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] EEG characteristics predict subsequent epilepsy in children with their first unprovoked seizure.2015

    • Author(s)
      Kanemura H, Sano F, Ohyama T, Mizorogi S, Aihara M.
    • Journal Title

      Epilepsy Res

      Volume: 115 Pages: 58-62

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 併存障害のない注意欠陥/多動性障害児におけるquality of lifeの検討2015

    • Author(s)
      佐野史和、金村英秋、青柳閣郎、反頭智子、相原正男.
    • Journal Title

      脳と発達

      Volume: 47 Pages: 349-353

    • NAID

      130005111618

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 発達障害と関連の深い身体疾患・神経疾患2014

    • Author(s)
      相原正男
    • Journal Title

      精神科治療学

      Volume: 29 Pages: 21-24

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Open Access / Acknowledgement Compliant
  • [Journal Article] 前頭葉の発達とその障害2014

    • Author(s)
      青柳閣郎、保坂裕美、相原正男
    • Journal Title

      認知神経科学

      Volume: 16 Pages: 49-54

    • NAID

      130006895772

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Developmental changes in frontal lobe function during a verbal fluency task: a multi-channel near-infrared spectroscopy study2014

    • Author(s)
      Tando T, Kaga Y, Ishii S, Aoyagi K, Sano F, Kanemura H, Sugita K, Aihara M.
    • Journal Title

      Brain Dev

      Volume: 36 Pages: 844-852

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Depressive symptoms contribute to quality of life in children with epilepsy.2014

    • Author(s)
      Sano F, Kanemura H, Tando T, Goto Y, Hosaka H, Sugita K, Aihara M
    • Journal Title

      Eur J Paediatr Neurol

      Volume: 18 Pages: 774-779

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Asymmetry of the prefrontal lobe in patients with attention deficit/hyperactivity disorder: A 3-D volumetric MRI study2014

    • Author(s)
      Kanemura H, Sano F, Ohyama T, Hosaka H, Sugita K, Aihara M.
    • Journal Title

      J Pediatr Neurol

      Volume: 12 Pages: 482-488

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Developmental changes in frontal lobe function during a verbal fluency task: a multi-channel near-infrared spectroscopy study.2014

    • Author(s)
      Tando T, Kaga Y, Ishii S, Aoyagi K, Sano F, Kanemura H, Sugita K, Aihara M.
    • Journal Title

      Brain Dev

      Volume: 36 Pages: 1-5

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cognitive and behavioral consequences in children with epilepsy: the relationship between paroxysmal EEG abnormalities and cognitive/behavioral disturbances.2013

    • Author(s)
      Kanemura H, Aihara M.
    • Journal Title

      Pediat Therapeut

      Volume: 3 Issue: 02 Pages: 1-4

    • DOI

      10.4172/2161-0665.1000151

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] EEG improvements with antiepileptic drug treatment can show a high correlation with behavior recovery in children with ADHD.2013

    • Author(s)
      Kanemura H, Sano F, Tando T, Hosaka H, Sugita K, Aihara M.
    • Journal Title

      Epilepsy Behav

      Volume: 27 Pages: 443-448

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Can EEG characteristics predict development of epilepsy in autistic children?2013

    • Author(s)
      Kanemura H, Sano F, Tando T, Sugita K, Aihara M.
    • Journal Title

      Eur J Paediatr Neurol

      Volume: 17 Pages: 232-237

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 小児期の前頭葉の機能的・形態的発達の不思議2016

    • Author(s)
      相原正男
    • Organizer
      第46回日本臨床神経生理学会学術集会
    • Place of Presentation
      ホテルハマツ(福島県・郡山市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 小児期の前頭葉の機能的・形態的発達の不思議2016

    • Author(s)
      相原正男
    • Organizer
      第46回日本臨床神経生理学会
    • Place of Presentation
      福島県福島市
    • Year and Date
      2016-10-27
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 認知神経科学よりみた社会脳の発達とその障害 -発達障害を理解するために-2016

    • Author(s)
      相原正男
    • Organizer
      第15回日本自閉症スペクトラム学会
    • Place of Presentation
      白百合女子大学講堂(東京都・世田谷区)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 社会脳の成長と発達2016

    • Author(s)
      相原正男
    • Organizer
      第21回認知神経科学会学術集会
    • Place of Presentation
      東京都文京区東京大学武田ホール
    • Year and Date
      2016-08-06
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 社会脳の発達2016

    • Author(s)
      相原正男
    • Organizer
      第21回認知神経科学会学術集会
    • Place of Presentation
      東京大学武田ホール(東京都・文京区)
    • Year and Date
      2016-08-05
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 発達障害とてんかん.2015

    • Author(s)
      相原正男
    • Organizer
      第3回障がいのある子どものてんかんを考える会.
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2015-11-11
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] シンポジウム:AD/HDの報酬/文脈の障害は情動系の未熟性による2015

    • Author(s)
      加賀佳美、相原正男
    • Organizer
      日本臨床神経生理学会
    • Place of Presentation
      大阪国際会議場(大阪府・大阪市)
    • Year and Date
      2015-11-05 – 2015-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 認知神経科学よりみた発達障害2015

    • Author(s)
      相原正男
    • Organizer
      プライマリケア医等・発達障害対応力向上研修会.
    • Place of Presentation
      香川県高松市
    • Year and Date
      2015-10-18
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 発達障害の医学2015

    • Author(s)
      相原正男
    • Organizer
      発達障害セミナー.
    • Place of Presentation
      東京都江東区有明
    • Year and Date
      2015-08-06
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 発達障害の医学2015

    • Author(s)
      相原正男
    • Organizer
      発達障害実践セミナー
    • Place of Presentation
      東京ファッションタウン(東京都・お台場)
    • Year and Date
      2015-08-06
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] シンポジウム:ADHDにおける情動性自律反応が実行機能に及ぼす影響2014

    • Author(s)
      後藤裕介、相原正男
    • Organizer
      日本臨床神経生理学会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2014-11-19 – 2014-11-21
    • Related Report
      2014 Research-status Report
  • [Presentation] シンポジウム:発達障害児におけるてんかん性突発波と抗てんかん薬による治療効果との関連2014

    • Author(s)
      金村英秋、相原正男
    • Organizer
      認知神経科学会
    • Place of Presentation
      東京大学(東京都・文京区)
    • Year and Date
      2014-07-26 – 2014-07-27
    • Related Report
      2014 Research-status Report
  • [Presentation] シンポジウムII. 小児の認知・情動発達―発達障害を理解するために―.2013

    • Author(s)
      青柳閣郎、相原正男.
    • Organizer
      第18回日本認知神経科学会学術集会
    • Place of Presentation
      東京大学先端知ビル武田ホール
    • Related Report
      2013 Research-status Report
  • [Presentation] 前頭葉の認知/情動機能の発達2013

    • Author(s)
      相原正男
    • Organizer
      第43回日本臨床神経生理学会
    • Place of Presentation
      高知県立県民文化ホール
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] シンポジウム14. 注意欠陥/多動性障害の病態生理2013

    • Author(s)
      相原正男.
    • Organizer
      第43回日本臨床神経生理学会
    • Place of Presentation
      高知県立県民文化ホール
    • Related Report
      2013 Research-status Report
  • [Presentation] 発達障害とは-医療の視点から-.

    • Author(s)
      相原正男
    • Organizer
      発達障害実践セミナー(公益社団法人発達協会)
    • Place of Presentation
      東京ファションタウンビル(台場)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 社会脳を育む

    • Author(s)
      18) 相原正男
    • Organizer
      山梨県特別支援教育管理職会議
    • Place of Presentation
      山梨県教育センター(笛吹)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] Neurodevelopmental disorders and the frontal lobes2017

    • Author(s)
      Aihara M
    • Total Pages
      300
    • Publisher
      Elsevier
    • Related Report
      2016 Annual Research Report
  • [Book] 看護学生のための神経内科学テキスト2016

    • Author(s)
      青柳閣郎、 相原正男.
    • Total Pages
      362
    • Publisher
      中外医学社
    • Related Report
      2015 Research-status Report
  • [Book] Executive Functions in Healthy and Disease2016

    • Author(s)
      Aihara M
    • Total Pages
      500
    • Publisher
      Elsevier
    • Related Report
      2015 Research-status Report
  • [Book] 小児の臨床神経生理―ベッドサイドで役立つ見方・考え方―2015

    • Author(s)
      加我牧子、相原正男、稲垣真澄(編)
    • Total Pages
      178
    • Publisher
      診断と治療社
    • Related Report
      2015 Research-status Report
  • [Book] 小児の臨床神経生理2015

    • Author(s)
      相原正男
    • Total Pages
      180
    • Publisher
      診断と治療社
    • Related Report
      2014 Research-status Report
  • [Book] 臨床医のための小児精神医療入門2014

    • Author(s)
      相原正男
    • Total Pages
      236
    • Publisher
      医学書院
    • Related Report
      2014 Research-status Report
  • [Book] 子どもの神経発達「臨床医のための子どもの心の診療入門」2014

    • Author(s)
      相原正男ほか48名、齋藤万比古、小平雅基編
    • Total Pages
      226
    • Publisher
      医学書院
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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