| Project/Area Number |
25461541
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
Fukuda Tokiko 浜松医科大学, 医学部, 准教授 (10458268)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGIE Hideo 常葉大学, 保健医療学部, 教授 (60119980)
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| Research Collaborator |
MATSUBAYASHI Tomoko
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ポンペ病 / マイクロRNA / Pompe病 / miRNA / バイオマーカー / biomarker / exome |
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| Outline of Final Research Achievements |
In order to explore new therapeutic methods for Pompe disease, microRNA expression profile was analyzed in Pompe skeletal muscles. microRNAs expression analysis by using 3D-GENE Scanner 3000 revealed expression of miR-499a-5p, miR-206, miR-208b-3p decreased to approximately 40% in the Pompe disease skeletal muscle. This microRNAs expression profile was different from the expression which reported in Duchenne muscular dystrophy muscles. As to the expression of microRNA regarding as participating in controlling autophagy, The reduction of the expression of miR-30a-3p which restrained expression of BECN1 was suggested.
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