Gonadal function and fertility preservation of childhood cancer survivor
| Project/Area Number |
25461544
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Osaka University |
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Principal Investigator |
MIYOSHI YOKO 大阪大学, 医学系研究科, 講師 (40457023)
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| Co-Investigator(Kenkyū-buntansha) |
筒井 建紀 大阪大学, 医学系研究科, 准教授 (00294075)
瀧内 剛 大阪大学, 医学部附属病院, 助教 (40733358)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 妊孕性温存 / 小児がん / 小児がん経験者 / 晩期合併症 / 性線機能 / 妊孕性 / 性腺機能異常 / 妊孕性低下 / 妊孕性温存治療 / 抗ミュラー管ホルモン / がん・生殖医療 / 卵巣予備能 |
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| Outline of Final Research Achievements |
Gonadal dysfunction and infertility are major endocrinological late effects among childhood cancer survivors. Chemotherapy and radiation have gonadotoxic effects and diminish the ovarian reserve. We have reported the endocrinological abnormalities and gonadal dysfunction of among childhood cancer survivors (CCSs). We have displayed that the serum concentration of anti-Mullerian hormone (AMH) concentration was a useful marker of ovarian reserve in CCSs. We conducted a longitudinal study to investigate the variations of AMH in evaluating the acute and chronic effects of cancer therapy on the ovary. The different patterns in the recovery phase demonstrated that the AMH levels just immediately after the end of cancer therapy is inappropriate for the evaluation of the ovarian reserve.
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Report
(5 results)
Research Products
(43 results)
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[Journal Article] Gonadal function, fertility, and reproductive medicine in childhood and adolescent cancer patients: a national survey of Japanese pediatric endocrinologists2016
Author(s)
Miyoshi Y, Yorifuji T, Horikawa R, Takahashi I, Nagasaki K, Ishiguro H, Fujiwara I Ito J, Oba M, Kawamoto H, Fujisaki H, Kato M, Shimizu C, Kato T, Matsumoto K, Sago H, Takimoto T, Okada H, Suzuki N, Yokoya S, Ogata T, Ozono K
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Journal Title
Clinical Pediatric Endocrinology
Volume: 25
Issue: 2
Pages: 45-57
DOI
NAID
ISSN
0918-5739, 1347-7358
Related Report
Peer Reviewed / Open Access
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[Journal Article] Low serum concentrations of anti-Mullerian hormone are common in 53 female childhood cancer survivors2014
Author(s)
Miyoshi Y, Ohta H, Namba N, Tachibana M, Miyamura T, Miyashita E, Hashii Y, Oue T, Isobe A, Tsutsui T, Kimura T, Ozono K
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Journal Title
Hormone Research in Paediatrics
Volume: 79
Issue: 1
Pages: 17-21
DOI
Related Report
Peer Reviewed
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