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Development of an effective intervention method for childhood metabolic syndrome in terms of the incretin system

Research Project

Project/Area Number 25461551
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionTottori University

Principal Investigator

HANAKI KEIICHI  鳥取大学, 医学部, 教授 (20238041)

Co-Investigator(Kenkyū-buntansha) KANZAKI SUSUMU  鳥取大学, 医学部, 教授 (90224873)
Research Collaborator KIMUARA SHINJI  
KANAYAMA SHUNSUKE  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords小児肥満 / メタボリックシンドローム / 食事摂取量 / 多価不飽和脂肪酸 / インクレチン経路 / 不飽和脂肪酸 / インクレチン / 食物嗜好
Outline of Final Research Achievements

There was no difference in the degree of obesity between children with higher and lower dietary intake of n-3 polyunsaturated fatty acids. The children with higher intake of n-3 polyunsaturated fatty acids showed higher protein (esp. animal protein) daily intake in contrast with a lower carbohydrate energy ratio. It is emphasized that a tailor-made, that is, based on the individual characteristics of food preference and dietary intake pattern, intervention should be provided upon dietary guidance for obese children, instead of instructing only energy reduction.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (25 results)

All 2016 2015 2014 2013

All Journal Article (10 results) (of which Peer Reviewed: 5 results) Presentation (10 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Book (5 results)

  • [Journal Article] 肥満とやせ2016

    • Author(s)
      花木啓一、金山俊介
    • Journal Title

      小児内科

      Volume: 48(3) Pages: 309-314

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Heterozygous nonsense mutations near the C-terminal region of IGF1R in two patients with small-for-gestational-age-related short stature.2015

    • Author(s)
      Fujimoto M, Kawashima Sonoyama Y, Hamajima N, Hamajima T, Kumura Y, Miyahara N, Nishimura R, Adachi K, Nanba E, Hanaki K, Kanzaki S.
    • Journal Title

      Clin Endocrinol (Oxf)

      Volume: 83(6) Issue: 6 Pages: 834-41

    • DOI

      10.1111/cen.12791

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肥満による健康問題2015

    • Author(s)
      花木啓一
    • Journal Title

      小児内科

      Volume: 47(8) Pages: 312-317

    • Related Report
      2015 Annual Research Report
  • [Journal Article] A rare <i>CYP 21</i> mutation (p.E431K) induced deactivation of CYP 21A2 and resulted in congenital adrenal hyperplasia2015

    • Author(s)
      Kawashima Y, Usui T, Fujimoto M, Miyahara N, Nishimura R, Hanaki K, Kanzaki S
    • Journal Title

      Endocrine Journal

      Volume: 62 Issue: 1 Pages: 101-106

    • DOI

      10.1507/endocrj.EJ14-0437

    • NAID

      130004699222

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gender differences in childhood food preference: evaluation using a subjective picture choice method2014

    • Author(s)
      Kimura S, Endo Y, Minamimae K, Kanzaki S, Hanaki K
    • Journal Title

      Pediatrics International

      Volume: 56 Issue: 3 Pages: 389-394

    • DOI

      10.1111/ped.12276

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 肥満と肥満症・メタボリックシンドローム2014

    • Author(s)
      花木啓一
    • Journal Title

      小児内科

      Volume: 46巻増刊号 Pages: 745-751

    • Related Report
      2014 Research-status Report
  • [Journal Article] 小児肥満の現状と今後の対策2014

    • Author(s)
      花木啓一
    • Journal Title

      小児科臨床

      Volume: 67(12) Pages: 2437-2442

    • Related Report
      2014 Research-status Report
  • [Journal Article] 小児肥満にみられる健康障害に関して2014

    • Author(s)
      花木啓一
    • Journal Title

      肥満研究

      Volume: 20(2) Pages: 21-22

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Familial short stature is associated with a novel dominant-negative heterozygous insulin-like growth factor 1 receptor (IGF1R) mutation2014

    • Author(s)
      Kawashima Y, Hakuno F, Okada SI, Hotsubo T, Kinoshita T, Fujimoto M, Nishimura R, Fukushima T, Hanaki K, Takahashi SI, Kanzaki S
    • Journal Title

      Clinical Endocrinology (Oxf)

      Volume: Epub ahead of print Issue: 2 Pages: 1-3

    • DOI

      10.1111/cen.12317

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 小児肥満と遺伝2013

    • Author(s)
      花木啓一
    • Journal Title

      小児保健研究

      Volume: 72(5) Pages: 621-626

    • NAID

      10031201904

    • Related Report
      2013 Research-status Report
  • [Presentation] タッチパネルデバイスを用いた新しい小児の食行動評価方法の開発:~食事への関心・嗜好の評価~2015

    • Author(s)
      木村真司、遠藤有里、南前恵子、花木啓一
    • Organizer
      第36回日本肥満学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of eating behavior evaluation method using touch panel devices in childhood: evaluation of food interest and preference2015

    • Author(s)
      Shinji Kimura, Yuri Endo, Keiko Minamimae, Keiichi Hanaki
    • Organizer
      The 8th Asia-Oceania Conference on Obesity
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 小児期の神経性食欲不振症発症リスクに関する研究ータブレットPCによる身体イメージ評価法を用いてー2015

    • Author(s)
      金山俊介、青戸春香、遠藤有里、南前恵子
    • Organizer
      第62回日本小児保健協会学術集会
    • Place of Presentation
      長崎市ブリックホール(長崎市)
    • Year and Date
      2015-06-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 小児悪性疾患経験者の心理社会的適応について2015

    • Author(s)
      勝部貴也、山根艶麗、吉川 優、金山俊介、青戸春香、遠藤有里、南前恵子、 上山潤一、 神崎 晋、花木啓一
    • Organizer
      第62回日本小児保健協会学術集会
    • Place of Presentation
      長崎市ブリックホール(長崎市)
    • Year and Date
      2015-06-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 小児肥満とメタボリックシンドローム:個人と社会の生活習慣2015

    • Author(s)
      花木啓一
    • Organizer
      第47回若年者心疾患・生活習慣病対策協議会総会
    • Place of Presentation
      リーガロイヤルホテル(広島市)
    • Year and Date
      2015-01-31 – 2015-02-01
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 小児の肥満とメタボリックシンドローム2014

    • Author(s)
      花木啓一
    • Organizer
      第36回西三河地区学校保健研究大会
    • Place of Presentation
      豊田市民文化会館(豊田市)
    • Year and Date
      2014-11-12
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 小児期の神経性食欲不振症発症リスクに関する研究2014

    • Author(s)
      金山俊介,青戸春香,遠藤有里,南前恵子, 渡邊仁美, 長石純一, 神崎晋, 花木啓一
    • Organizer
      第61回日本小児保健協会学術集会
    • Place of Presentation
      福島グリーンパレス(福島市)
    • Year and Date
      2014-06-20 – 2014-06-22
    • Related Report
      2014 Research-status Report
  • [Presentation] イラスト選択法を用いた小児の食物嗜好の評価の試み2013

    • Author(s)
      木村真司遠藤有里、南前恵子、酒井知恵子、花木啓一
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Research-status Report
  • [Presentation] EVALUATION OF FOOD PREFERENCE IN CHILDHOOD USING A PICTURE CHOICE METHOD: A RELATIONSHIP WITH BODY HABITUS.2013

    • Author(s)
      Shinji Kimura, Yuri Endo, Keiko Minamimae, Susumu Kanzaki, Keiichi Hanaki
    • Organizer
      Asia-Pacific Diabetes and Obesity Study Group symposium 2013
    • Place of Presentation
      Tokyo International Forum
    • Related Report
      2013 Research-status Report
  • [Presentation] 小児肥満と遺伝2013

    • Author(s)
      花木啓一
    • Organizer
      第30回小児保健協会小児保健セミナー
    • Place of Presentation
      ベルサール九段, 東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 小児内分泌学テキスト2016

    • Author(s)
      花木啓一
    • Total Pages
      350
    • Publisher
      診断と治療社
    • Related Report
      2015 Annual Research Report
  • [Book] 小児肥満症ガイドライン2016

    • Author(s)
      花木啓一
    • Total Pages
      260
    • Publisher
      日本肥満学会
    • Related Report
      2015 Annual Research Report
  • [Book] 小児・思春期糖尿病コンセンサス・ガイドライン2015

    • Author(s)
      花木啓一
    • Publisher
      南江堂
    • Related Report
      2014 Research-status Report
  • [Book] 今日の治療指針 第16版2015

    • Author(s)
      花木啓一
    • Publisher
      医学書院
    • Related Report
      2014 Research-status Report
  • [Book] 肥満・肥満症・メタボリック症候群. 小児科学レクチャー2013

    • Author(s)
      花木啓一
    • Total Pages
      3
    • Publisher
      総合医学社
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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