| Project/Area Number |
25461553
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Ehime University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
Suzuki Yuka 愛媛大学, 大学院医学系研究科, 寄附講座准教授 (00304634)
Tanaka Junya 愛媛大学, 大学院医学系研究科, 教授 (70217040)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
Ishizaki Yoshito 九州大学, 大学病院, 助教 (20572944)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 熱性痙攣 / 側頭葉てんかん / HMGB－１ / 分子標的 / ラット / 海馬 / 脳波 / アストログリア / HMGB1 / 熱性けいれん / 後天性てんかん / アストログリオーシス / てんかん / けいれん重積 / ヌクレオカイン / 海馬細胞障害 / 内側側頭葉てんかん |
|---|
| Outline of Final Research Achievements |
We investigated the role of HMGB1 in febrile seizures (FS) and secondary acquired epilepsy associated with febrile status epilepticus using hyperthermia-induced seizures (HS) in immature rats, a model of human FS. HMGB1 enhanced HS, but did not induce any hippocampal damage. HMGB1 also enhanced acquired epilepsy after febrile status epilepticus using hyperthermia-induced seizures (HS), and histological analysis showed that astrocytes were significantly increased in the hippocampus and the corpus callosum in rats having acquired epilepsy. Our results indicate that infantile prolonged febrile seizures with HMGB1 overproduction could enhance adulthood epileptogenesis and might contribute to the development of mesial temporal lobe epilepsy. Further, astrogliosis also should play an important role in acquired epileptogenesis.
|
