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High mobility group box 1 enhanced febrile seizures and acquired epilepsy in a rodent model of infantile febrile seizures

Research Project

Project/Area Number 25461553
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionEhime University

Principal Investigator

Fukuda Mitsumasa  愛媛大学, 医学部附属病院, 准教授 (80274330)

Co-Investigator(Kenkyū-buntansha) Suzuki Yuka  愛媛大学, 大学院医学系研究科, 寄附講座准教授 (00304634)
Tanaka Junya  愛媛大学, 大学院医学系研究科, 教授 (70217040)
Co-Investigator(Renkei-kenkyūsha) Ishizaki Yoshito  九州大学, 大学病院, 助教 (20572944)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords熱性痙攣 / 側頭葉てんかん / HMGB-1 / 分子標的 / ラット / 海馬 / 脳波 / アストログリア / HMGB1 / 熱性けいれん / 後天性てんかん / アストログリオーシス / てんかん / けいれん重積 / ヌクレオカイン / 海馬細胞障害 / 内側側頭葉てんかん
Outline of Final Research Achievements

We investigated the role of HMGB1 in febrile seizures (FS) and secondary acquired epilepsy associated with febrile status epilepticus using hyperthermia-induced seizures (HS) in immature rats, a model of human FS. HMGB1 enhanced HS, but did not induce any hippocampal damage. HMGB1 also enhanced acquired epilepsy after febrile status epilepticus using hyperthermia-induced seizures (HS), and histological analysis showed that astrocytes were significantly increased in the hippocampus and the corpus callosum in rats having acquired epilepsy. Our results indicate that infantile prolonged febrile seizures with HMGB1 overproduction could enhance adulthood epileptogenesis and might contribute to the development of mesial temporal lobe epilepsy. Further, astrogliosis also should play an important role in acquired epileptogenesis.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (12 results)

All 2015 2014 2013 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 3 results) Presentation (6 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Postnatal interleukin-1beta administration after experimental prolonged febrile seizures enhances epileptogenesis in adulthood2015

    • Author(s)
      Fukuda, M, Ishii, E, et al.
    • Journal Title

      Metab Brain Dis

      Volume: in press Issue: 3 Pages: 813-819

    • DOI

      10.1007/s11011-014-9648-7

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] KL-6 as a biomarker of respiratory complications in severely disabled children.2015

    • Author(s)
      Ochi F, Fukuda M, Ohmori H, Yano Y, Wakamoto H, Suzuki Y, Ishii E.
    • Journal Title

      Pediatr Int.

      Volume: in press Issue: 3 Pages: 439-442

    • DOI

      10.1111/ped.12537

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Carnitine deficiency: risk factors and incidence in children with epilepsy.2015

    • Author(s)
      Fukuda M, Kawabe M, Takehara M, IWANO S, Kuwabara K, Kikuchi C, Wakamoto H, Morimoto T, Suzuki Y, Ishii E.
    • Journal Title

      Bra Dev.

      Volume: in press Issue: 8 Pages: 790-796

    • DOI

      10.1016/j.braindev.2014.12.004

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Postnatal interleukin-1β enhances adulthood seizure susceptibility and neuronal cell death after prolonged experimental febrile seizures in infantile rats.2014

    • Author(s)
      Fukuda M, Hino H, Suzuki Y, Takahashi H, Morimoto T, Ishii E.
    • Journal Title

      Acta Neurol Belg.

      Volume: 114 Issue: 3 Pages: 179-185

    • DOI

      10.1007/s13760-013-0246-y

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Postnatal interleukin-1β enhances adulthood seizure susceptibility and neuronal cell death after prolonged experimental febrile seizures in infantile rats.2014

    • Author(s)
      Fukuda M, Hino H, Suzuki Y, Takahashi H, Morimoto T, Ishii E.
    • Journal Title

      Acta Neurol Belg

      Volume: (in press)

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] High mobility group box 1 after infantile experimental prolonged febrile seizures enhances acquired epileptogenesis in adulthood2015

    • Author(s)
      Ito M, Fukuda M, Yano H, Yano Y, Tanaka J, Ishii E
    • Organizer
      第49回日本てんかん学会学術集会
    • Place of Presentation
      長崎県長崎市
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Toll-like receptor 3 activation enhances hyperthermia-induced seizures in immature rats.2015

    • Author(s)
      Fukuda M, Ito M, Yano Y, Sakuma H, Hayashi M
    • Organizer
      第57回日本小児神経科学会学術集会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Postnatal interleukin-1β after experimental prolonged febrile seizures enhances epileptogenesis in adulthood2014

    • Author(s)
      Mitsumasa Fukuda, Masanori Ito, Yoshiaki Yano, Hisaaki Takahashi, Takehiko Morimoto, Yuka Suzuki, and Eiichi Ishii
    • Organizer
      the 10th Asian & Oceanian Epilepsy Congress
    • Place of Presentation
      Singapore
    • Year and Date
      2014-08-07 – 2014-08-10
    • Related Report
      2014 Research-status Report
  • [Presentation] High mobility group box 1 enhances hyperthermia-induced seizures in developing rats.2014

    • Author(s)
      Masanori Ito, Mitsumasa Fukuda, Yoshiaki Yano, Hisaaki Takahashi, Yuka Suzuki, Takehiko Morimoto, and Eiichi Ishii
    • Organizer
      the 10th Asian & Oceanian Epilepsy Congress
    • Place of Presentation
      Singapore
    • Year and Date
      2014-08-07 – 2014-08-10
    • Related Report
      2014 Research-status Report
  • [Presentation] High mobility group box 1 enhances hyperthermia-induced seizures in developing rats.

    • Author(s)
      Masanori Ito, Mitsumasa Fukuda, Yoshiaki Yano, Hisaaki Takahashi, Yuka Suzuki, Takehiko Morimoto, and Eiichi Ishii
    • Organizer
      7th IGAKUKEN International Symposium
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Research-status Report
  • [Presentation] Animal models for the study of febrile seizures and acquired epileptogenesis.

    • Author(s)
      Mitsumasa Fukuda, Masanori Ito, Yoshiaki Yano, Yuka Suzuki, Hisaaki Takahashi, Takehiko Morimoto, Eiichi Ishii
    • Organizer
      7th IGAKUKEN International Symposium
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 子どものけいれん・てんかんガイド、分担執筆『 熱性けいれんと憤怒けいれん』2013

    • Author(s)
      福田光成
    • Publisher
      中山書店
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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