| Project/Area Number |
25461556
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORITAKE HIROSHI 宮崎大学, 医学部生殖発達医学講座小児科学分野, 准教授 (40336300)
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| Co-Investigator(Renkei-kenkyūsha) |
DATE YUKARI 宮崎大学フロンティア科学実験総合センター, 生理活性物質研究部門・生理活性物質機能解析分野, 教授 (70381100)
AKIEDA SAYAKA 宮崎大学フロンティア科学実験総合センター, 生理活性物質研究部門・生理活性物質機能解析分野, 准教授 (20549076)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Mfsd2 / ノックアウトマウス |
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| Outline of Final Research Achievements |
We demonstrated that rat Mfsd2 plays a role in body growth. These result suggest that Mfsd2 influence nutrition and hormones. However, there was no difference between KO mouse and WT mouse in levels of blood IGF-1 or sex hormones. No difference was found histologically in tissues of the liver, white adipose tissue or muscle. Nor could any significant difference be found in the expression of metabolism-related genes (G6PDase and PEKCK) or fatty acid beta-oxidation enzymes (CPT1a, Acad, Acox1).
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