| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We investigated the role of Arcadlin on synaptic plasticity such as epileptic seizure or learning and memory. We found that the development of amygdala kindling was facilitated in arcadlin knockout mice（ko）compared to wild type mice (wt). In addition, the day until 5 repetitive general convulsion was significantly less in ko. The walking velocity was significantly higher and the distance was significantly longer in ko compared to wt in open field test. The latency to enter the light area first from the dark area was significantly shorter in ko compared to wt in dark-light test. In Morris water maze test there was a significant delay in the latency to reach the goal plat form in young ko compared to wt.
Our study revealed that Arcadlin suppresses development of epileptic seizure and facilitates learning and memory in an age-dependent manner.
Furthermore, Arcadlin might have a role on attention deficit hyperactivity disorder (ADHD).
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