Development of diagnostic biomarker of mitochondrial disorders
Project/Area Number |
25461571
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
|
Research Institution | Kurume University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
YATSUGA Shuichi 久留米大学, 医学部小児科, 助教 (10454919)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | ミトコンドリア脳筋症 / バイオマーカー / 感度・特異度 / GDF15 / 診断アルゴリズム / 体外診断薬開発 / 重症度分類 / 薬物治療 / 効果判定 / 高乳酸血症 / メタボローム解析 / 診断システム / ミトコンドリア病 / 医薬品開発 / 評価指標 / 創薬研究 |
Outline of Final Research Achievements |
Mitochondrial disorders, an intractable genetic disease, is the disorders who have not produce enough ATP generation. Using rho zero cellular model, we have identified GDF15, which is the most useful and reliable mitochondrial biomarker for diagnosis and monitor the clinical progression in mitochondrial disorders. We have been developing the testing device of GDF15 and doing the clinical trial for application for diagnostic device in Japan.
|
Report
(4 results)
Research Products
(36 results)
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[Journal Article] Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders.2015
Author(s)
Yatsuga S, Fujita Y, Ishii A, Fukumoto Y, Arahata H, Kakuma T, Kojima T, Ito M, Tanaka M, Saiki R, Koga Y.
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Journal Title
Ann Neurol
Volume: 78
Issue: 5
Pages: 814-823
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs protein translation and contributes to myopathy in mice and humans.2015
Author(s)
Wei FY, Zhou B, Suzuki T, Miyata K, Ujihara Y, Horiguchi H, Takahashi N, Xie P, Michiue H, Fujimura A, Kaitsuka T, Matsui H, Koga Y, Mohri S, Suzuki T, Oike Y, Tomizawa K.
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Journal Title
Cell Metab
Volume: 21
Issue: 3
Pages: 413-6
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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