| Project/Area Number |
25461578
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
AZUMA Hiroshi 旭川医科大学, 医学部, 教授 (00167909)
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| Co-Investigator(Kenkyū-buntansha) |
古谷野 伸 旭川医科大学, 医学部, 講師 (30312458)
長森 恒久 旭川医科大学, 医学部, 助教 (40400098)
高橋 弘典 旭川医科大学, 医学部, 助教 (50431408)
岡嶋 一樹 旭川医科大学, 大学病院, 医員 (70213931)
酒井 宏水 奈良県立医科大学, 医学部, 教授 (70318830)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | リポソーム / MDSC / immunosuppression / liposome / ナノ粒子 / マクロファージ / iNOS / ectosome / B7-H3 / regulatory macrophage / B7 family / CD276 |
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| Outline of Final Research Achievements |
Myeloid-derived suppressor cell (MDSC) appears in various pathological condition and suppress T cell immune response. Although cell-to-cell contact between MDSC and T cell is required for the suppression, the molecules involved in the contact remains unknown. When liposome particles are intravenously injected into rat, Considerable amount of MDSC-like cells (liposome-internalized cells) can rapidly accumulate in spleen. We further addressed its ability to produce cytokine. At the same time, tried to search the molecules involved in the cell-to-cell contact. Like MDSC, MDSC-like cells produce more IL-10 than normal macrphage. DNA microarray analysis revealed that B7-H3 message was amplified and cell surface expression B7-H3 was enhanced. Therefore, it is suggested that liposome can induce MDSC-like cells in vivo and B7-H3 molecules might be involved in T cell suppression.
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