| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We established a mouse model, in which after epicutaneous sensitization, allergic diarrhea was induced by initial oral ingestion of an antigen and thereby we examined effects of skin lesion on the induced symptoms of food allergy. After development of food allergy caused by epicutaneous sensitization, continuous exacerbation of the skin lesion deteriorated the oral antigen induced allergic symptoms. Epicutaneous application of steroid improved the skin lesions, leading to suppression of food allergy symptoms. Infants with atopic dermatitis often comorbid with food allergy. Our results suggest that after epicutaneous sensitization, even initial intake of food could induce allergic symptoms and that control of skin lesion is important to prevent the development of food allergy symptoms as well as food elimination.
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