Development of epicutaneous immunotherapy for food allergy using indution of regulatory T cells
Project/Area Number |
25461583
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | University of Fukui |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 食物アレルギー / 経皮感作 / アトピー性皮膚炎 / IgE / アナフィラキシー / 動物モデル / 制御性細胞 / ビタミンD3 |
Outline of Final Research Achievements |
We established a mouse model, in which after epicutaneous sensitization, allergic diarrhea was induced by initial oral ingestion of an antigen and thereby we examined effects of skin lesion on the induced symptoms of food allergy. After development of food allergy caused by epicutaneous sensitization, continuous exacerbation of the skin lesion deteriorated the oral antigen induced allergic symptoms. Epicutaneous application of steroid improved the skin lesions, leading to suppression of food allergy symptoms. Infants with atopic dermatitis often comorbid with food allergy. Our results suggest that after epicutaneous sensitization, even initial intake of food could induce allergic symptoms and that control of skin lesion is important to prevent the development of food allergy symptoms as well as food elimination.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Japanese Guideline for Food Allergy 20142014
Author(s)
A. Urisu, M. Ebisawa, K. Ito, Y. Aihara, S. Ito, M. Mayumi, Y. Kohno, N. Kondo, Y. Ohshima, Committee of Japanese Pediatric Guideline for Food
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Journal Title
Allergology International
Volume: 63
Issue: 3
Pages: 399-419
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed
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[Presentation] 食物アレルギーの基礎と臨床2014
Author(s)
大嶋 勇成
Organizer
Kyoto 60 Medical Meeting
Place of Presentation
京都タワーホテル(京都市)
Year and Date
2014-08-30
Related Report
Invited
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