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Endosomal sorting signal of cytokine receptors and its single nucleotide polymorphism in allergy disease

Research Project

Project/Area Number 25461586
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionShinshu University

Principal Investigator

TAKESHITA Toshikazu  信州大学, 学術研究院医学系, 教授 (60212023)

Co-Investigator(Renkei-kenkyūsha) KOJIMA Katsuhiko  信州大学, 学術研究院医学系, 講師 (80345743)
YOSHINO Kazuhisa  信州大学, 学術研究院医学系, 助教 (40551859)
AMANO Yuji  信州大学, 学術研究院医学系, 助教 (50624681)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsサイトカイン / サイトカイン受容体 / アレルギー / 受容体遺伝子多型 / 小胞輸送シグナル
Outline of Final Research Achievements

In lymphoid cell, intracellular compartments, which keep the specific substances of the system and exchanges the substances between the compartments, is supported by endosomal sorting. Here, we elucidated endosomal sorting mechanism of interleukin-2 receptor β (IL-2Rβ) and interleukin-4 receptor α (IL-4Rα), and explored single nucleotide polymorphism (SNP) of the receptors in allergy patients. We identified novel SNPs in IL-4Rα gene locus of the patients. On the other hand, the SNP involved in endosomal sorting was not detected in the patients.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation2014

    • Author(s)
      Kojima, K., Amano, Y., Yoshino, K., Tanaka, N., Sugamura, K., Takeshita, T.
    • Journal Title

      J Biol Chem

      Volume: 289 Issue: 48 Pages: 33296-33310

    • DOI

      10.1074/jbc.m114.578245

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A hydrophobic amino acid cluster inserted into the C-terminus of a recycling cell surface receptor functions as an endosomal sorting signal2013

    • Author(s)
      Amano Y., Yoshino K., Kojima K., Takeshita T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 441 Issue: 1 Pages: 164-168

    • DOI

      10.1016/j.bbrc.2013.10.019

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Hydrophobic amino acid cluster in the cytoplasmic tail of interleukin-2 receptor βchain acts as a sorting signal for lysosome

    • Author(s)
      天野勇治、その他
    • Organizer
      国際免疫学会
    • Place of Presentation
      ミラノ(イタリア)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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