Propranolol therapy for intractable hemangioma and lymphangioma
Project/Area Number |
25461587
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Gifu University |
Principal Investigator |
OZEKI MICHIO 岐阜大学, 医学部附属病院, 助教 (60444303)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 小児腫瘍学 / 血管腫 / リンパ管腫 / 薬物療法 / 乳児血管腫 / プロプラノロール / VEGF / リンパ管疾患 / 血管奇形 / 新規治療 |
Outline of Final Research Achievements |
Propranolol has recently been shown to be highly effective for infantile hemangiomas (IHs). However, the therapeutic mechanism of action of propranolol and the usefulness of measurement of vascular endothelial growth factor (VEGF) remains poorly understood. This study aimed to determine the efficacy of propranolol treatment on various features and to evaluate changes in plasma VEGF levels in patients with IH who underwent propranolol treatment.The study group consisted of 35 children with IH. Oral propranolol was administered at a dose of 2.0 mg/kg/day and was divided in three doses. Plasma VEGF concentrations were analyzed by enzyme-linked immunoabsorbent assay, and the values between the groups were compared. VEGF concentrations 4 weeks after treatment were significantly lower than those before treatment (p < 0.01). We conclude that measurement of VEGF may be a useful tool for predicting the course of hemangioma and monitoring the effectiveness of treatment.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] リンパ管腫2014
Author(s)
藤野明浩, 上野滋, 岩中督, 木下義晶, 小関道夫, 森川康英, 黒田達夫
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Journal Title
小児外科
Volume: 46
Pages: 1181-1186
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[Presentation] Nationwide Study of Lymphangiomatosis and Gorham-Stout disease in Japan.2014
Author(s)
Michio Ozeki, Tomohiro Hori, Kaori Kanda, Eiko Matsui, Toshiyuki Fukao, Naomi Kondo, Kentaro Matsuoka, Shunsuke Nosaka, Akihiro Fujino, Tatsuo Kuroda,
Organizer
第56回日本小児血液がん学会
Place of Presentation
岡山
Year and Date
2014-11-30
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[Presentation] Nationwide Study of Lymphangiomatosis and Gorham-Stout disease in Japan.2014
Author(s)
Michio Ozeki, Tomohiro Hori, Kaori Kanda, Eiko Matsui, Toshiyuki Fukao, Naomi Kondo, Kentaro Matsuoka, Shunsuke Nosaka, Akihiro Fujino, Tatsuo Kuroda,
Organizer
The 20th International Workshop of the International Society for the Study of Vascular Anomalies
Place of Presentation
オーストラリア、メルボルン
Year and Date
2014-04-02
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[Presentation] Propranolol for intractable lymphatic malformation (lymphangioma): a report of 4 cases.2013
Author(s)
Fujino A, Ozeki M, Kanamori Y, Tanka H, Watanabe T, Takeda N, Yamada W, Takahashi M, Yamada K, Ishihama H
Organizer
ISSVA 2012(International Society of Studying Vascular Anomaly, 国際血管奇形研究学会)
Place of Presentation
マルメ、スウェーデン
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