Elucidation and control of molecular mechanism in WT1 peptide vaccine therapy after allogeneic hematopoietic stem cell transplantation
| Project/Area Number |
25461592
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岡 芳弘 大阪大学, 医学系研究科, 特任教授(常勤) (20273691)
宮村 能子 大阪大学, 医学系研究科, 助教 (20379796)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 小児がん / 同種造血細胞移植後 / WT1 / ペプチドワクチン / がん免疫 / 同種造血細胞移植 / 小児血液悪性腫瘍 / がんワクチン / 造血細胞移植 / 早期探索臨床試験 / 同種移植後免疫療法 / 免疫モニタリング / 小児血液腫瘍 / 同種造血幹細胞移植 / 癌ワクチン |
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| Outline of Final Research Achievements |
A WT1 peptide vaccine targeting the WT1 protein was developed and clinical research was carried out "Allogeneic Immunotherapy Postoperative Phase 2 Study on Patients With Intractable Pediatric Blood Tumors Using WT1 Vaccine". Registration example 18 cases were analyzed. Among them, 4 out of 7 patients remained in remission in non remission phase transplant group and revealed that it is effective in pediatric hematologic malignancy. We found that WT1 - specific killer T cells were significantly increased by flow cytometry compared with that before inoculation, and that the rate of increase was high in remission surviving cases, and it was clarified that it is useful as a biomarker. I could create a new concept of "maintenance therapy by WT1 vaccination after hematopoietic cell transplantation".
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Report
(5 results)
Research Products
(24 results)
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[Presentation] WT1vaccination for pediatric malignancies.2015
Author(s)
Yoshiko Hashii
Organizer
First Sino-US-Japan Pediatric Translational Medicine Forum and Third International Pediatric Hematology and Oncology
Place of Presentation
Songshan Hall and Tiansha Hall(China)
Year and Date
2015-11-14
Related Report
Int'l Joint Research / Invited
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