Molecular basis of central neurvous invasion of pediatric leukemia
| Project/Area Number |
25461593
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Shimane University |
|---|
Principal Investigator |
FUKDUA SEIJI 島根大学, 医学部, 教授 (30273147)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 急性骨髄性白血病 / 細胞遊走 / 浸潤 / FLT/ITD / CXCL12 / CXCR4 / 急性白血病 / ケモカイン / 髄外浸潤 / 中枢神経浸潤 / 白血病細胞浸潤 / 白血病細胞遊走異常 |
|---|
| Outline of Final Research Achievements |
One of the major indicators of poor prognosis in leukemia patients is extramedullary infiltration or dissemination of leukemia cells. In particular, leukemia cell infiltration into the central nervous system is one of the major complications negatively influencing prognosis. However, little is known about the mechanisms responsible for extramedullary dissemination of leukemia cells compared to those responsible for solid tumor metastasis. In the present study, we have identified molecular mechanism responsible for the enhanced chemotaxis towards chemokine CXCL12 that is induced by the Internal Tandem Duplication mutation of FLT3 gene (FLT3/ITD) associated with extremely poor prognosis. We subsequently investigated if antagonizing this particular molecular mechanism can be utilized for the treatment to block the unnecessary migration of the hematopoietic cells with FLT3/ITD.
|
Report
(5 results)
Research Products
(13 results)
