Analysis of the factor of low immune responses to pneumococcal conjugate vaccine and Hemophilus influenzae type b conjugate vaccine in immunocompromised children
Project/Area Number |
25461598
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | University of Occupational and Environmental Health, Japan |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
NISHIO Hisanori 九州大学, 大学病院, 助教 (00507783)
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Co-Investigator(Renkei-kenkyūsha) |
OHGA Shiouichi 山口大学, 医学部, 教授 (60233053)
OISHI Kazunori 国立感染症研究所, 感染症疫学センター, センター長 (80160414)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 免疫不全 / 結合型肺炎球菌ワクチン / 免疫応答低下 / メモリーB細胞 / ヘルパーT細胞 / 感染症学 / 予防医学 / 免疫学 |
Outline of Final Research Achievements |
The aim of this study is to investigate the factor of low immune response to pneumococcal conjugate vaccine and Hemophilus influenzae type b conjugate vaccine in immunocompromised children. We measured anti-pneumococcal IgG antibodies and opsonization index and anti-Hemophilus influenzae type b antibody and serum bactericidal antibody after the vaccinations in immunocompromised children [children who underwent hematopoietic stem cell transplantation (HSCT) and the patients with immunosuppressive treatments] and immunocompetent children. Anti-pneumococcal IgG antibodies and opsonization index in the patient after HSCT were significantly lower than those in immunoponpetent children. In addition, memory B cell and CD4+ T cell counts in the patients after HSCT were lower than those in immunocompetent children, suggesting that these cells might have an important role in the immune response to conjugate vaccine.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] Memory B-cell pools predict the immune response to pneumococcal conjugate vaccine in immunocompromised children2016
Author(s)
Takayuki Hoshina, Shouichi Ohga, Junko Fujiyoshi, Etsuro Nanishi, Tomoko Takimoto, Shunsuke Kanno, Hisanori Nishio, Mitsumasa Saito, Yukihiko Akeda, Kazunori Oishi, Toshiro Hara
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Journal Title
Journal of Infectious Diseases
Volume: 213
Issue: 5
Pages: 848-855
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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