| Project/Area Number |
25461598
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIO Hisanori 九州大学, 大学病院, 助教 (00507783)
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| Co-Investigator(Renkei-kenkyūsha) |
OHGA Shiouichi 山口大学, 医学部, 教授 (60233053)
OISHI Kazunori 国立感染症研究所, 感染症疫学センター, センター長 (80160414)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 免疫不全 / 結合型肺炎球菌ワクチン / 免疫応答低下 / メモリーＢ細胞 / ヘルパーＴ細胞 / 感染症学 / 予防医学 / 免疫学 |
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| Outline of Final Research Achievements |
The aim of this study is to investigate the factor of low immune response to pneumococcal conjugate vaccine and Hemophilus influenzae type b conjugate vaccine in immunocompromised children.
We measured anti-pneumococcal IgG antibodies and opsonization index and anti-Hemophilus influenzae type b antibody and serum bactericidal antibody after the vaccinations in immunocompromised children [children who underwent hematopoietic stem cell transplantation (HSCT) and the patients with immunosuppressive treatments] and immunocompetent children. Anti-pneumococcal IgG antibodies and opsonization index in the patient after HSCT were significantly lower than those in immunoponpetent children. In addition, memory B cell and CD4+ T cell counts in the patients after HSCT were lower than those in immunocompetent children, suggesting that these cells might have an important role in the immune response to conjugate vaccine.
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