Demonstration of global coagulation assays and the suppression mechanism about acquired coagulation disorders
| Project/Area Number |
25461605
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOGAMI Keiji 奈良県立医科大学, 医学部, 准教授 (50326328)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 後天性凝固異常症 / 凝固因子 / インヒビター / 凝固機能評価 / 抑制メカニズム / 抗リン脂質抗体 / 活性化プロテインC / von willebrand factor / 活性化プロテインC抵抗性 / 第V因子 |
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| Outline of Final Research Achievements |
Acquired coagulation factor inhibitors occur rarely, but may develop spontaneously haemorrhage symptoms as autoantibodies in previously normal individuals. However, the suppression mechanism is not clear. In the existence group, the decrease, no group of procoagulant activities elucidated activation protein C-resistant presence in the presence or absence of haemorrhage symptoms in acquired factor V inhibitor. Also, the coagulation function rating system to grasp clinical condition is essential. We established coagulation and fibrinolysis ability evaluation by Thrombin/Plasmin, quickly VWF measurement by the new diagnostic methods. A approach using clot waveform analysis provided useful means of differentiating coagulation defects in inhibitor patients with a prolonged aPTT.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Elevated plasma factor VIII enhances venous thrombus formation in rabbits: contribution of factor XI, von Willebrand factor and tissue factor.2013
Author(s)
Sugita C, Yamashita A, Matsuura Y, Iwakiri T, Okuyama N, Matsuda S, Matsumoto T, Inoue O, Harada A, Kitazawa T, Hattori K, Shima M, Asada Y.
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Journal Title
Thrombosis and Haemostasis
Volume: 110
Pages: 62-75
Related Report
Peer Reviewed
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