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Genome- and gene expression-based drug discovery for pediatric Philadelphia chromosome positive leukemia

Research Project

Project/Area Number 25461608
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionKeio University

Principal Investigator

SHIMADA HIROYUKI  慶應義塾大学, 医学部, 講師 (80265868)

Co-Investigator(Kenkyū-buntansha) SHIMA HARUKO  慶應義塾大学, 医学部, 助教 (80424167)
Co-Investigator(Renkei-kenkyūsha) KIYOKAWA NOBUTAKA  独立行政法人国立成育医療研究センター, 小児血液・腫瘍研究部, 部長 (60195401)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords慢性骨髄性白血病 / フィラデルフィア染色体陽性急性リンパ性白血病 / IKZF1遺伝子 / ゲノム解析 / 慢性骨髄性白血 / IKZF1遺伝 / エピゲノム解析 / トランスクリプトーム解析
Outline of Final Research Achievements

Deletion of IKZF1 gene was reported to be found in 80% of pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL), which is known to be refractory leukemia. We examined the association between IKZF1 deletion and prognosis of 40 Ph+ALL patients, who was registered into the JPLSG Ph+ALL04 study. As a result, 4-year event-free survival was 89% in patients without IKZF1 deletion and 42% in patients with IKZF1 deletion. Patients with IKZF1 deletion had a significantly higher rate of relapse than those without IKZF1 deletion. These results suggest that the reason why Ph+ALL is refractory is not the appearance of Ph-chromosome but deletion of IKZF1.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2015 2014

All Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Interim Analysis of a Multicenter, Prospective Study for Pediatric Chronic Myeloid Leukemia in Chronic Phase: The JPLSG CML-08 Study2015

    • Author(s)
      Hiroyuki Shimada
    • Organizer
      American Society of Hematology Annual Meeting
    • Place of Presentation
      オーランド(アメリカ)
    • Year and Date
      2015-12-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A multicenter, prospective observational study for pediatric CML in CP (JPLSG CML-08):Preliminary analysis 20142014

    • Author(s)
      Hiroyuki Shimada, Hidemitsu Kurosawa, Akihiro Watanabe, Masaki Ito, Chikako Tono, Haruko Shima, Yuki Yuza, Hideki Muramatsu, Noriko Hotta, Masahiko Okada, Akihiko Tanizawa
    • Organizer
      日本小児血液・がん学会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2014-11-28 – 2014-11-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 小児フィラデルフィア染色体陽性急性リンパ性白血病(Ph+ALL)におけるIKZF1遺伝子欠失と予後との関連2014

    • Author(s)
      嶋田博之、佐藤 篤、河崎裕英、松本公一、加藤 格、児玉祐一、加藤啓輔、工藤寿子、齋藤明子、足立壮一、堀部敬三、水谷修紀、真部淳
    • Organizer
      日本造血細胞移植学会総会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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