Genome- and gene expression-based drug discovery for pediatric Philadelphia chromosome positive leukemia
Project/Area Number |
25461608
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
|
Research Institution | Keio University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
SHIMA HARUKO 慶應義塾大学, 医学部, 助教 (80424167)
|
Co-Investigator(Renkei-kenkyūsha) |
KIYOKAWA NOBUTAKA 独立行政法人国立成育医療研究センター, 小児血液・腫瘍研究部, 部長 (60195401)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 慢性骨髄性白血病 / フィラデルフィア染色体陽性急性リンパ性白血病 / IKZF1遺伝子 / ゲノム解析 / 慢性骨髄性白血 / IKZF1遺伝 / エピゲノム解析 / トランスクリプトーム解析 |
Outline of Final Research Achievements |
Deletion of IKZF1 gene was reported to be found in 80% of pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL), which is known to be refractory leukemia. We examined the association between IKZF1 deletion and prognosis of 40 Ph+ALL patients, who was registered into the JPLSG Ph+ALL04 study. As a result, 4-year event-free survival was 89% in patients without IKZF1 deletion and 42% in patients with IKZF1 deletion. Patients with IKZF1 deletion had a significantly higher rate of relapse than those without IKZF1 deletion. These results suggest that the reason why Ph+ALL is refractory is not the appearance of Ph-chromosome but deletion of IKZF1.
|
Report
(4 results)
Research Products
(3 results)
-
-
[Presentation] A multicenter, prospective observational study for pediatric CML in CP (JPLSG CML-08):Preliminary analysis 20142014
Author(s)
Hiroyuki Shimada, Hidemitsu Kurosawa, Akihiro Watanabe, Masaki Ito, Chikako Tono, Haruko Shima, Yuki Yuza, Hideki Muramatsu, Noriko Hotta, Masahiko Okada, Akihiko Tanizawa
Organizer
日本小児血液・がん学会
Place of Presentation
岡山コンベンションセンター
Year and Date
2014-11-28 – 2014-11-30
Related Report
-