| Project/Area Number |
25461610
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IHIRA Masaru 藤田保健衛生大学, 医療科学部, 教授 (10290165)
KAWAMURA Yoshiki 藤田保健衛生大学, 医学部, 助教 (30581475)
松岡 恵里奈 藤田保健衛生大学, 医学部, 助教 (80648494)
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| Co-Investigator(Renkei-kenkyūsha) |
OHASHI Masahiro 豊川市民病院, 小児科, 医長 (90308883)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ロタウイルス / 脳炎 / 突然死 / 病態 / 疫学調査 / リアルタイムRT-PCR / ワクチン株 / 愛知県 / 重症合併症 / 脳症 / バイオマーカー / 抗原血症 / 全国調査 |
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| Outline of Final Research Achievements |
It has been suggested that replication of rotavirus in intestinal tissue is not important for pathogenesis of severe complications such as encephalitis and sudden unexpected death. Additionally, no remarkable findings suggesting direct invasion of virus into central nervous system were demonstrated in this study. Thus, present data suggests that host immune response may play important role in pathogenesis of these severe complications. Incidence of these severe complications in Japan were estimated based on the epidemiological analysis carried out in Aichi prefecture. After starting support of vaccination cost from the local governments, number of the cases with severe rotavirus associated complications appears to be declined. Further follow up study is necessary to confirm this finding.
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