| Project/Area Number |
25461618
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Niigata University |
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Principal Investigator |
Ikezumi Yohei 新潟大学, 医歯学総合病院, 講師 (70361897)
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| Co-Investigator(Kenkyū-buntansha) |
Kawachi Hiroshi 新潟大学, 医歯学系, 教授 (60242400)
Suzuki Toshiaki 新潟大学, 医歯学総合病院, 助教 (50419305)
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| Co-Investigator(Renkei-kenkyūsha) |
Narita Ichiei 新潟大学, 医歯学系, 教授 (20272817)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | M2型活性化マクロファージ / 慢性腎臓病 / 尿細管間質線維化 / 糸球体硬化 / ステロイド抵抗性ネフローゼ症候群 / 酸化LDL / 線維化 / Ｍ２型活性化マクロファージ / 酸化ＬＤＬ / ステロイド / ネフローゼ症候群 |
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| Outline of Final Research Achievements |
The role of alternatively activated macrophages (M2) in progression of chronic kidney disease was examined by immunohistological staining of biopsy specimen and in vitro studies using human monocyte-derived macrophage.
We found that M2 exerted an anti-inflammatory effect at the site of inflamed-tissue, while playing a role in the progression of chronic lesions. In addition, we found that steroid, a widely used drug in the treatment of kidney diseases, could augment the chronic lesion. Combined treatment with antimetabolite could counteract the steroid-induced M2 activation, and might be useful for the treatment of CKD.
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