Occult HBV infection in children

• Project/Area Number: 25461625
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Nagoya City University
• Principal Investigator: ITO KOICHI 名古屋市立大学, 医学(系)研究科(研究院), 助教 (00444977)
• Co-Investigator(Kenkyū-buntansha): SUGIURA Tokio 名古屋市立大学, 医学研究科, 講師 (10381881)
• Co-Investigator(Renkei-kenkyūsha): TANAKA Yasuhito 名古屋市立大学, 医学研究科, 教授 (90336694)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: HBV / 小児 / 母子感染 / ワクチン / Ｂ型肝炎 / B型肝炎

Outline of Final Research Achievements

【Background/Aims】Presence of occult HBV infection in HBV vaccinated children remains largely unknown. The aim of　this study was to investigate the prevalence of occult HBV infection among HBV vaccinated children in Japan.【Methods】HBsAg negative sera from vaccinated children were enrolled. The titers of HBV DNA were determined by Real-time PCR.【Results】Anti-HBc was detected in 45 (67%) children. Among these,26 subjects were analyzed by Real-time PCR. Seven out of 26 (27%) subjects were HBV DNA positive. The titers of HBV DNA were so low that the results need to be interpreted carefully. To clarify the precise prevalence of occult HBV infection in children, further study is needed.

Research Products

• [Journal Article] Molecular Genetic Dissection and Neonatal/Infantile Intrahepatic Cholestasis Using Targeted Next-Generation Sequencing (2016)
  • Author(s): Togawa T, Sugiura T, Ito K, Endo T, Aoyama K, Ohashi K, Negishi Y, Kudo T, Ito R, Kikuchi A, Arai-Ichinoi N, Kure S, Saitoh S.
  • Journal Title: J Pediatr. Volume: 171 Pages: 171-177
  • DOI: 10.1016/j.jpeds.2016.01.006
  • Peer Reviewed
• [Journal Article] Effects of 4-phenylbutyrate therapy in a preterm infant with cholestasis and liver fibrosis (2016)
  • Author(s): Ito S, Hayashi H, Sugiura T, Ito K, Ueda H, Togawa T, Endo T, Tanikawa K, Kage M, Kusuhara H, Saitoh S.
  • Journal Title: Pediatr Int. Volume: Feb 4 Issue: 6 Pages: 506-509
  • DOI: 10.1111/ped.12839
  • Peer Reviewed
• [Journal Article] Single nucleotide polymorphisms in AGTR1, TFAP2B, and TRAF1 are not associated with the incidence of patent ductus arteriosus in Japanese preterm infants. (2016)
  • Author(s): Kawase K, Sugiura T, Nagaya Y, Yamada T, Sugimoto M, Ito K, Togawa T, Nagasaki R, Kato T, Kouwaki M, Koyama N, Saitoh S.
  • Journal Title: Pediatr Int. Volume: Nov 30 Issue: 6 Pages: 461-466
  • DOI: 10.1111/ped.12861
  • Peer Reviewed
• [Journal Article] 高ウイルス量妊婦へのテノホビル投与によるB型肝炎ウイルス母子感染予防 (2016)
  • Author(s): 大江雅美子,杉浦時雄,遠藤剛,伊藤孝一,齋藤伸治
  • Journal Title: 日本周産期･新生児医学会雑誌 Volume: 52 Pages: 165-168
  • Peer Reviewed
• [Journal Article] Effects of tolvaptan on congestive heart failure complicated with chylothorax in a neonate. (2015)
  • Author(s): Sato N, Sugiura T, Nagasaki R, Suzuki K, Ito K, Kato T, Inukai S, Saitoh S.
  • Journal Title: Pediatr Int. Volume: 57 Issue: 5 Pages: 1020-1022
  • DOI: 10.1111/ped.12697
  • Peer Reviewed
• [Journal Article] Viral load before and after exchange transfusion in a neonate with hyperbilirubinemia and congenital cytomegalovirus infection (2014)
  • Author(s): Ohashi K, Ito K, Endo T, Sugiura T, Awaya R, Goto T, Nagaya Y, Ueda H, Nagasaki R, Kato T, Saitoh S.
  • Journal Title: J Clin Case Rep Volume: 4 Issue: 03 Pages: 1-2
  • DOI: 10.4172/2165-7920.1000343
  • Peer Reviewed / Open Access
• [Presentation] 高ウイルス量妊婦へのテノホビル投与によるB型肝炎ウイルス母子感染予防 (2016)
  • Author(s): 立川雅美子, 杉浦時雄, 遠藤剛, 伊藤孝一, 齋藤伸治, 田中靖人
  • Organizer: 第119回日本小児科学会学術集会
  • Place of Presentation: ロイトン札幌（北海道・札幌）
  • Year and Date: 2016-05-14
• [Presentation] ペグインターフェロン治療中にHBe抗原セロコンバージョンが得られたB型慢性肝炎5歳例 (2016)
  • Author(s): 伊藤孝一, 遠藤剛, 杉浦時雄, 齋藤伸治
  • Organizer: 第119回日本小児科学会学術集会
  • Place of Presentation: さっぽろ芸術文化の館（北海道・札幌）
  • Year and Date: 2016-05-13
• [Presentation] de novo B型肝炎予防のためにエンテカビルを使用した腎芽腫の女児例 (2015)
  • Author(s): 伊藤孝一, 遠藤剛, 杉浦時雄, 齋藤伸治
  • Organizer: 第32回日本小児肝臓研究会
  • Place of Presentation: 鳥取大学医学部（鳥取県・米子市）
  • Year and Date: 2015-07-25
• [Presentation] B型肝炎ウイルス母子感染予防の新方式は周知されているか? (2015)
  • Author(s): 伊藤彰悟, 杉浦時雄, 伊藤孝一, 加藤丈典, 齋藤伸治
  • Organizer: 第51回日本周産期・新生児医学会学術集会
  • Place of Presentation: ヒルトン福岡シーホーク（福岡県・福岡市）
  • Year and Date: 2015-07-10
• [Presentation] 当県におけるB型肝炎ウイルス母子感染予防の実態と キャリア妊婦の頻度 (2015)
  • Author(s): 杉浦時雄
  • Organizer: 第51回日本肝臓学会総会
  • Place of Presentation: ホテル日航熊本,熊本
  • Year and Date: 2015-05-21 – 2015-05-22
• [Presentation] 疫学からみたウイルス肝炎対策 当県におけるB型肝炎ウイルス母子感染予防の実態とキャリア妊婦の頻度 (2015)
  • Author(s): 杉浦時雄, 遠藤剛, 伊藤孝一
  • Organizer: 第 51 回日本肝臓学会総会
  • Place of Presentation: ホテル日航熊本（熊本県・熊本市）
  • Year and Date: 2015-05-21
• [Presentation] 小児のOccult HBV感染の実態調査 (2014)
  • Author(s): 伊藤孝一
  • Organizer: 第41回日本小児栄養消化器肝臓学会
  • Place of Presentation: 東京ステーションコンファレンス,東京
  • Year and Date: 2014-10-11 – 2014-10-12