| Project/Area Number |
25461627
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
NISHIDA MASASHI 京都府立医科大学, 医学(系)研究科(研究院), 講師 (50275202)
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| Co-Investigator(Kenkyū-buntansha) |
HAMAOKA KENJI 京都府立医科大学, 医学研究科, 教授 (60189602)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 先天性心疾患 / 急性腎障害 / 慢性腎臓病 / 腎機能 / 尿中アルブミン / 尿中L型脂肪酸結合蛋白 / 尿中β2-ミクログロブリン / 造影剤腎症 / シスプラチン / 急性腎不全 |
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| Outline of Final Research Achievements |
We studied renal function in 38 children with congenital heart disease aged more than 6 years, and compared those with the history of acute kidney injury (AKI) following cardiac operation to those without the history of AKI. In patients with the history of AKI, although neither the deterioration of renal function nor proteinuria was evident, albuminuria was noted, and marked elevation of both urinary L-type fatty acid-binding protein (L-FABP) and urinary β2-microglobulin was observed following the administration of contrast agent. These data suggested the existence of latent disorder of glomerular and tubular function in these patients, which may lead to chronic kidney disease (CKD) with the insult to the kidney, such as the drug and the ischemia.
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