| Project/Area Number |
25461633
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAYAMA EMIKO 東京女子医科大学, 医学部, 非常勤講師 (00349698)
NAKANISHI TOSHIO 東京女子医科大学, 医学部, 研究生 (90120013)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | QT延長症候群 / 多価不飽和脂肪酸 / EPA/AA / EPA/AA比 / PUFA |
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| Outline of Final Research Achievements |
In the myocardial Na + channel (Nav1.5), INa suppression was observed in both of the cell with the ω-3 PUFA (EPA) or ω-6 -PUFA (AA). In the long QT syndrome (LQTS) patients, the mean value of the concentration ratio of EPA and AA (EPA / AA ratio), showed a low value compared with the value of the general Japanese. In the group of 20 years of age or older with a syncope episode, EPA / AA ratio had an significant low value compared to the value of the group with no syncope episode. PUFA was found to modulate the Nav1.5 channel. The low-EPA / AA ratio raises the risk of syncope episode was considered.
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