The clarification of the pathophysiology of small bacterial overgrowth in neurologically impaired patient by using non-invasive technique
Project/Area Number |
25461636
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Kurume University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
八木 実 久留米大学, 医学部, 教授 (10251802)
浅桐 公男 久留米大学, 医学部, 准教授 (90268946)
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 小腸内細菌増殖 / 重症心身障害児 / 水素呼気テスト / 胆道閉鎖症 / 胃食道逆流症 / 胃排出能 / 食道インピーダンス / C13呼気ガス分析 / C13呼気ガス分析 |
Outline of Final Research Achievements |
Hydrogen breath test was conducted for 33 case of neurologically impaired patients (mean: 19.0 years, ranged 1 to 58 years). Three and 6 cases of all patients were determined as positive and pseudo-positive small bowel bacterial overgrowth (SBO), respectively. All cases administered anticonvulsant and one case administered gastric secretion inhibitor. All enrolled cases were not diagnosed as gastroesophageal reflux disease (GERD) by esophageal impedance monitoring, whereas demonstrated delayed gastric emptying (132.9-241.3 min). The present study suggested that approximately 10% of neurologically impaired patients potentially suffers SBO although there was no significant relationship between SBO and clinical parameters, drugs, GERD and delayed gastric emptying, statistically.
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Report
(5 results)
Research Products
(16 results)
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[Journal Article] A baseline impedance analysis in neurologically impaired children: A potent parameter for estimating the condition of the esophageal mucosa.2017
Author(s)
Suguru Fukahori*, Minoru Yagi*, Shinji Ishii*, Kimio Asagiri*, Nobuyuki Saikusa*, Naoki Hashizume*, Motomu Yoshida*, Daisuke Masui*, Naoko komatsuzaki*, Naruki Higashidate*, Hirotomo Nakahara* and Yoshiaki Tanaka* **
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Journal Title
Neurogastroenterology and Motility
Volume: 29
Issue: 6
DOI
Related Report
Peer Reviewed
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[Journal Article] The characteristics of salivary pepsin in patients with severe motor and intellectual disabilities2017
Author(s)
Hashizume N, Fukahori S, Asagiri K, Ishii S, Saikusa N, Higashidate N, Yoshida M, Masui D, Sakamoto S, Tanaka Y, Yagi M, Yamashita Y
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Journal Title
Brain and Development
Volume: 未定
Related Report
Peer Reviewed
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[Journal Article] Severe delayed gastric emptying induces non-acid reflux up to proximal esophagus in neurologically impaired patients2017
Author(s)
Shinji Ishii, Suguru Fukahori, Kimio Asagiri, Yoshiaki Tanaka, Nobuyuki Saikusa, Naoki Hashizume, Motomu Yoshida, Daisuke Masui, Naoko Komatsuzaki, Naruki Higashidate, Saki Sakamoto, Tomohiro Kurahachi, Shiori Tsuruhisa, Hirotomo Nakahara and Minoru Yagi
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Journal Title
Journal of Neurogastroenterology and Motility
Volume: 未定
Related Report
Peer Reviewed
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[Journal Article] Laparoscopic Nissen fundoplication mainly reduces the volume of acid reflux and potentially improves mucosal integrity up to the middle esophagus in neurologically impaired children detected by esophageal combined pH-multichannel intraluminal impedance measurements2016
Author(s)
Suguru Fukahori*, Minoru Yagi*, Shinji Ishii*, Kimio Asagiri*, Nobuyuki Saikusa*, Naoki Hashizume*, Motomu Yoshida*, Daisuke Masui*, Saki Sakamoto*, Shihori Tsuruhisa*, Tomohiro Kurahachi* and Yoshiaki Tanaka* **
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Journal Title
Journal of Pediatric Surgery
Volume: 51
Pages: 1283-7
Related Report
Peer Reviewed / Int'l Joint Research
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