| Project/Area Number |
25461637
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Yokohama City University (2014-2015)
National Research Institute for Child Health and Development (2013) |
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Principal Investigator |
ITO Shuichi 横浜市立大学, 医学(系)研究科(研究院), 教授 (20336572)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Hitoshi 独立行政法人国立成育医療研究センター, 器官病態系内科部, 院長 (70214393)
MATSUOKA Kentaro 独立行政法人国立成育医療研究センター, 病理診断部, 医長 (90286443)
ABE Jun 独立行政法人国立成育医療研究センター, 免疫アレルギー研究部, 室長 (40281688)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | チアノーゼ性腎症 / 先天性心疾患 / HIF-1α / VEGF / TNF-α / 蛋白尿 / チアノーゼ性心疾患 / VEGF-c / HIF |
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| Outline of Final Research Achievements |
We elucidated the pathophysiology of cyanotic nephropathy associated with congenital heart disease (CHD), which is a severe complication of cyanotic CHD. In kidney tissue, glomerular hypertrophy, enlargement of capillary lumen, increase of mesangial cell and the matrix were observed, and positive immunohistochemistry staining with HIF-1αand VEGF in glomerular endothelial cells were also observed in all patients. These findings are negative in normal control. Although plasma level of VEGF and VEGF-a were not elevated in patients as compared to control, but plasma VEGF-c and TNF-α were significantly elevated in patients. Our study revealed HIF-1αand VEG expressed in glomerular endothelial cells could be involved in etiology of cyanotic nephropathy. Specific therapy targeting VEGF-c and TNF-α may be possible against cyanotic nephropathy.
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