Pathophysiology of cyanotic nephropathy associated with congenital heart disease
Project/Area Number |
25461637
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Yokohama City University (2014-2015) National Research Institute for Child Health and Development (2013) |
Principal Investigator |
ITO Shuichi 横浜市立大学, 医学(系)研究科(研究院), 教授 (20336572)
|
Co-Investigator(Kenkyū-buntansha) |
KATO Hitoshi 独立行政法人国立成育医療研究センター, 器官病態系内科部, 院長 (70214393)
MATSUOKA Kentaro 独立行政法人国立成育医療研究センター, 病理診断部, 医長 (90286443)
ABE Jun 独立行政法人国立成育医療研究センター, 免疫アレルギー研究部, 室長 (40281688)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | チアノーゼ性腎症 / 先天性心疾患 / HIF-1α / VEGF / TNF-α / 蛋白尿 / チアノーゼ性心疾患 / VEGF-c / HIF |
Outline of Final Research Achievements |
We elucidated the pathophysiology of cyanotic nephropathy associated with congenital heart disease (CHD), which is a severe complication of cyanotic CHD. In kidney tissue, glomerular hypertrophy, enlargement of capillary lumen, increase of mesangial cell and the matrix were observed, and positive immunohistochemistry staining with HIF-1αand VEGF in glomerular endothelial cells were also observed in all patients. These findings are negative in normal control. Although plasma level of VEGF and VEGF-a were not elevated in patients as compared to control, but plasma VEGF-c and TNF-α were significantly elevated in patients. Our study revealed HIF-1αand VEG expressed in glomerular endothelial cells could be involved in etiology of cyanotic nephropathy. Specific therapy targeting VEGF-c and TNF-α may be possible against cyanotic nephropathy.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Efficacy and safety of eculizumab in childhood atypical hemolytic uremic syndrome in Japan.2016
Author(s)
Ito N, Hataya H, Saida K, Amano Y, Hidaka Y, Motoyoshi Y, Ohta T, Yoshida Y, Terano C, Iwasa T, Kubota W, Takada H, Hara T, Fujimura Y, Ito S.
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Journal Title
Clin Exp Nephrol
Volume: 20
Issue: 2
Pages: 265-72
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Insignificant impact of VUR on the progression of CKD in children with CAKUT.2016
Author(s)
Ishikura K, Uemura O, Hamasaki Y, Nakai H, Ito S, Harada R, Hattori M, Ohashi Y, Tanaka R, Nakanishi K, Kaneko T, Iijima K, Honda M; Pediatric CKD Study Group in Japan in conjunction with the Committee of Measures for Pediatric CKD of the Japanese Society for Pediatric Nephrology
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Journal Title
Pediatr Nephrol
Volume: 31
Issue: 1
Pages: 105-112
DOI
Related Report
Peer Reviewed
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[Journal Article] Growth impairment in children with pre-dialysis chronic kidney disease in Japan.2015
Author(s)
Hamasaki Y, Ishikura K, Uemura O, Ito S, Wada N, Hattori M, Ohashi Y, Tanaka R, Nakanishi K, Kaneko T, Honda M
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Journal Title
Clin Exp Nephrol
Volume: 19
Issue: 6
Pages: 1142-1148
DOI
Related Report
Peer Reviewed
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[Journal Article] A multicenter randomized trial indicates initial prednisolone treatment for childhood nephrotic syndrome for two months is not inferior to six-month treatment2015
Author(s)
Yoshikawa N, Nakanishi K, Sako M, Oba MS, Mori R, Ota E, Ishikura K, Hataya H, Honda M, Ito S, Shima Y, Kaito H, Nozu K, Nakamura H, Igarashi T, Ohashi Y, Iijima K
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Journal Title
Kidney Int
Volume: 87
Issue: 1
Pages: 225-232
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Rituximab for the treatment of childhood-onset complicated frequently relapsing nephritic syndrome/steroid-dependent nephrotic syndrome: A multicentre, double-blind, randomised, placebo-controlled trial2014
Author(s)
Iijima K, Sako M, Nozu K, Mori R, Tuchida N, Kamei K, Muira K, Aya K, Nakanishi K, Ohtomo Y, Takahashi S, Tanaka R, Kaito H, Nakamura H, Ishikura K, Ito S, Ohhashi Y.
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Journal Title
Lancet
Volume: 384
Pages: 1273-81
Related Report
Acknowledgement Compliant
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[Journal Article] Japanese Study Group of Renal Disease in Children.Morbidity in children with frequently relapsing nephrosis: 10-year follow-up of a randomized controlled trial2014
Author(s)
Ishikura K, Yoshikawa N, Nakazato H, Sasaki S, Nakanishi K, Matsuyama T, Ito S, Hamasaki Y, Yata N, Ando T, Iijima K, Honda M
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Journal Title
Pediatr Nephro
Volume: 30(3)
Pages: 459-68
Related Report
Acknowledgement Compliant
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[Journal Article] X-Linked Alport Syndrome Caused by Splicing Mutations in COL4A5.2014
Author(s)
Nozu K, Vorechovsky I, Kaito H, Fu XJ, Nakanishi K, Hashimura Y, Hashimoto F, Kamei K, Ito S, Kaku Y, Imasawa T, Ushijima K, Shimizu J, Makita Y, Konomoto T, Yoshikawa N, Iijima K
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Journal Title
Clin J Am Soc Nephrol
Volume: 9
Pages: 1958-64
Related Report
Acknowledgement Compliant
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[Journal Article] A multicenter randomized trial indicates initial prednisolone treatment for childhood nephrotic syndrome for two months is not inferior to six-month treatment2014
Author(s)
Yoshikawa N, Nakanishi K, Sako M, Oba MS, Mori R, Ota E, Ishikura K, Hataya H, Honda M, Ito S, Shima Y, Kaito H, Nozu K, Nakamura H, Igarashi T, Ohashi Y, Iijima K.
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Journal Title
Kidney Int.
Volume: 87(1)
Pages: 225-32
Related Report
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[Journal Article] Cyclosporine C2 Monitoring for the Treatment of Frequently Relapsing Nephrotic Syndrome in Children: A Multicenter Randomized Phase II Trial.2014
Author(s)
Iijima K, Sako M, Oba MS, Ito S, Hataya H, Tanaka R, Ohwada Y, Kamei K, Ishikura K, Yata N, Nozu K, Honda M, Nakamura H, Nagata M, Ohashi Y, Nakanishi K, Yoshikawa N. : Japanese Study Group of Kidney Disease in Children.
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Journal Title
Clin J Am Soc Nephrol
Volume: 9(2)
Issue: 2
Pages: 271-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Pre-Dialysis chronic kidney disease in Children: results of a nationwide survey in Japan2013
Author(s)
Ishikura K, Uemura O, Ito S, Wada N, Hattori M, Ohashi Y, Hamasaki Y, Tanaka R, Nakanishi K, Kaneko T, Honda M; on behalf of the Pediatric CKD Study Group in Japan in conjunction with Committee of Measures of pediatric CKD of the Japanese Society of Pediatric Nephrology
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Journal Title
Dial Transplant
Volume: 28
Issue: 9
Pages: 2345-2355
DOI
Related Report
Peer Reviewed
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