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Pathogenesis of insufficient adrenocortical response in premature fetal sheep suffered from intrauterine inflammation

Research Project

Project/Area Number 25461638
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionTohoku University

Principal Investigator

Akiyama Shizuko  東北大学, 医学(系)研究科(研究院), 非常勤講師 (80466549)

Co-Investigator(Kenkyū-buntansha) MATSUDA TADASHI  東北大学, 病院, 准教授 (50361100)
SAITO MASATOSHI  東北大学, 病院, 講師 (00451584)
WATANABE TATSUYA  東北大学, 病院, 非常勤講師 (70400380)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords胎児 / 早産児 / 成育限界 / 子宮内炎症 / 副腎皮質ホルモン / CRH負荷試験 / ACTH / バゾプレッシン / 副腎皮質 / コーチゾル / 脳虚血 / 人工胎盤 / 超低出生体重児 / 相対的副腎不全 / アルギニン・バゾプレッシン
Outline of Final Research Achievements

We planed to clarify the effect of intrauterine inflammation on the cortisol secretion and its circulatory response in premature lamb because the fetal endocrine potential to adapt the postnatal environment might have been already deteriorated by the inflammatory stress before birth. In consequence, we could store the plasma samples for 45 times of the corticotrophin releasing hormone test. Unfortunately, however, commercial kits for immunoassay of sheep AVP, ACTH and cortisol could not be available domestically during the study period. Instead, we have been developing the method of peptides and steroid profiling analysis using the LC-MS/MS.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2013

All Journal Article (1 results)

  • [Journal Article] バゾプレッシンの循環器系に及ぼす影響.2013

    • Author(s)
      松田 直,加賀麻衣子,臼田治夫,伊藤智子,渡邊真平,小野寺幸子,新関昌枝,秋山志津子,北西隆太,渡邉達也.
    • Journal Title

      日本周産期・新生児医学会雑誌

      Volume: 49 Pages: 165-167

    • NAID

      10031176875

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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