Pathogenesis of insufficient adrenocortical response in premature fetal sheep suffered from intrauterine inflammation
| Project/Area Number |
25461638
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
Akiyama Shizuko 東北大学, 医学(系)研究科(研究院), 非常勤講師 (80466549)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUDA TADASHI 東北大学, 病院, 准教授 (50361100)
SAITO MASATOSHI 東北大学, 病院, 講師 (00451584)
WATANABE TATSUYA 東北大学, 病院, 非常勤講師 (70400380)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 胎児 / 早産児 / 成育限界 / 子宮内炎症 / 副腎皮質ホルモン / CRH負荷試験 / ACTH / バゾプレッシン / 副腎皮質 / コーチゾル / 脳虚血 / 人工胎盤 / 超低出生体重児 / 相対的副腎不全 / アルギニン・バゾプレッシン |
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| Outline of Final Research Achievements |
We planed to clarify the effect of intrauterine inflammation on the cortisol secretion and its circulatory response in premature lamb because the fetal endocrine potential to adapt the postnatal environment might have been already deteriorated by the inflammatory stress before birth. In consequence, we could store the plasma samples for 45 times of the corticotrophin releasing hormone test. Unfortunately, however, commercial kits for immunoassay of sheep AVP, ACTH and cortisol could not be available domestically during the study period. Instead, we have been developing the method of peptides and steroid profiling analysis using the LC-MS/MS.
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Report
(4 results)
Research Products
(1 results)
