Analysis of normal and abnormal development of human embryos using 3D imaging data
Project/Area Number |
25461642
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Embryonic/Neonatal medicine
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Research Institution | Kyoto University |
Principal Investigator |
Takakuwa Tetsuya 京都大学, 医学(系)研究科(研究院), 教授 (40244933)
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Co-Investigator(Kenkyū-buntansha) |
YAMADA Shigehito 京都大学, 大学院医学研究科, 教授 (80432384)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | ヒト胚子 / 形態形成 / 発生 / 3次元画像 / MRI / 位相CT / 先天異常 / 発生解剖 |
Outline of Final Research Achievements |
Insights into the dynamic and complex processes during organogenesis will require accurate 3D morphologic data with dynamic modeling of embryonic structures to elucidate the complex anatomic remodeling that occurs during these early embryonic stages. In this aspects, morphogenesis during early human embryonic periods, has been precisely analysed using the MR image, phase contrast CT, and serial histological sections. Those embryo and materials derived from the “Kyoto Collection” which is the largest collection of human embryo specimens in the world, stored at the Congenital Anomaly Research Center. We analysed morphogenesis of several main organs during embryonic and early-fetal period, such as brain, sense organ (optic and auditory organs), digestive tracts, spleen, liver, and knee joints. The obtained data will contribute to a better understanding of morphogenesis of human embryo, and serve as a useful reference for fetal medicine and prenatal diagnosis.
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Report
(4 results)
Research Products
(114 results)
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[Presentation] The current status of conventional prenatal diagnosis in Japan: A Nationwide survey of obstetrics/gynecology facilities2015
Author(s)
Miyake H, Yamada S, Fujii Y, Sawai H, Arimori N, Yamanuchi Y, Ozasa Y, Kanai M, Sago H, Sekizasa A, Takada F, Masuzaki H, Matsubara Y, Hirahara F, Kugu K
Organizer
21st The International Federation of Gynecology and Obstetrics (FIGO)
Place of Presentation
Vancouver, Canada
Year and Date
2015-10-04
Related Report
Int'l Joint Research
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[Presentation] Survey of conventional prenatal diagnosis in Japan - Nationwide study for obstetricians about prenatal diagnosis2015
Author(s)
Miyake H, Yamada S, Fujii Y, Sawai H, Arimori N, Yamanuchi Y, Ozasa Y, Kanai M, Sago H, Sekizasa A, Takada F, Masuzaki H, Matsubara Y, Hirahara F, Kugu K
Organizer
ISPD 19th International Conference on Prenatal Diagnosis and Therapy
Place of Presentation
Washington, District of Columbia, United States
Year and Date
2015-07-12
Related Report
Int'l Joint Research
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[Presentation] ヒト外耳初期発生過程の解析2014
Author(s)
尾関 舞美, 山田 重人, 上部千賀子, 石津 浩一, 高桑 徹也
Organizer
第54回日本先天異常学会学術集会
Place of Presentation
相模原市、麻布大学
Year and Date
2014-07-26 – 2014-07-27
Related Report
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[Presentation] ヒト消化管の初期形態形成と分化2014
Author(s)
上野 沙季, 山田 重人, 高桑 徹也
Organizer
第54回日本先天異常学会学術集会
Place of Presentation
相模原市、麻布大学
Year and Date
2014-07-26 – 2014-07-27
Related Report
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[Presentation] ヒト胚子期における脳形態形成の解析2014
Author(s)
白石 直樹, 片山 愛里, 中島 崇, 山田 重人, 上部千賀子, 巨瀬 勝美, 高桑 徹也
Organizer
第54回日本先天異常学会学術集会
Place of Presentation
相模原市、麻布大学
Year and Date
2014-07-26 – 2014-07-27
Related Report
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