| Project/Area Number |
25461645
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Embryonic/Neonatal medicine
|
|---|
| Research Institution | Kagawa University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOYANO Kosuke 香川大学, 医学部附属病院, 助教 (20437685)
MIKI Takanori 香川大学, 医学部, 教授 (30274294)
UENO Masaki 香川大学, 医学部, 教授 (30322267)
NAKAMURA Shinji 香川大学, 医学部, 助教 (30437686)
KUSAKA Takashi 香川大学, 医学部, 教授 (50274288)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 低酸素性虚血性脳症 / 動物モデル / 近赤外光 / 脳血液量 / 新生仔豚 / 新生児低酸素性虚血性脳症 / 低酸素虚血 / 動物実験 |
|---|
| Outline of Final Research Achievements |
In these studies, we found that combining the cerebral blood volume (CBV) with amplitude-integrated EEG (aEEG) is a more effective guide to control hypoxic/ischemic (HI) insult in a newborn piglet model than aEEG alone, to produce a consistent degree of survivable neuropathological damage. Next, we found that an early CBV increase and longer low-ampitude EEG after insult indicates severe brain injury. Finally, we revealed that Edaravone (a free radical scavenger) reduced histologic neuronal damage related to HI loading in our piglet HI model. However, we also found the histopathological damage, especially kidney tissue. We have to consider the systemic impact by Edaravone.
|
