Treatment strategy of neonatal hypoxic-ischemic encephalopathy using by newborn piglets asphyxia model
| Project/Area Number |
25461645
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOYANO Kosuke 香川大学, 医学部附属病院, 助教 (20437685)
MIKI Takanori 香川大学, 医学部, 教授 (30274294)
UENO Masaki 香川大学, 医学部, 教授 (30322267)
NAKAMURA Shinji 香川大学, 医学部, 助教 (30437686)
KUSAKA Takashi 香川大学, 医学部, 教授 (50274288)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 低酸素性虚血性脳症 / 動物モデル / 近赤外光 / 脳血液量 / 新生仔豚 / 新生児低酸素性虚血性脳症 / 低酸素虚血 / 動物実験 |
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| Outline of Final Research Achievements |
In these studies, we found that combining the cerebral blood volume (CBV) with amplitude-integrated EEG (aEEG) is a more effective guide to control hypoxic/ischemic (HI) insult in a newborn piglet model than aEEG alone, to produce a consistent degree of survivable neuropathological damage. Next, we found that an early CBV increase and longer low-ampitude EEG after insult indicates severe brain injury. Finally, we revealed that Edaravone (a free radical scavenger) reduced histologic neuronal damage related to HI loading in our piglet HI model. However, we also found the histopathological damage, especially kidney tissue. We have to consider the systemic impact by Edaravone.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Cerebral blood volume measurement using near-infrared time-resolved spectroscopy and histopathological evaluation after hypoxic-ischemic insult in newborn piglets.2015
Author(s)
Nakamura M, Jinnai W, Hamano S, Nakamura S, Koyano K, Chiba Y, Kanenishi K, Yasuda S, Ueno M, Miki T, Hata T, Kusaka T.
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Journal Title
International Journal of Developmental Neuroscience
Volume: 42
Issue: 1
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Relationship between early changes in cerebral blood volume and electrocortical activity after hypoxic-ischemic insult in newborn piglets.2014
Author(s)
Nakamura S, Kusaka T, Koyano K, Miki T, Ueno M, Jinnai W, Yasuda S, Nakamura M, Okada H, Isobe K, Itoh S.
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Journal Title
Brain Dev
Volume: 36
Issue: 7
Pages: 563-571
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Developmental Change of Visual Cognitive Function of Infancy2015
Author(s)
Yukihiko Konishi, Ikuko Kato, Rie Tomita, Hiromi Suzuki, Hitoshi Okada, Wataru Jinnai, Kousuke Koyano, Saneyuki Yasuda, Tomoko Nishida, Yoshitaka Matsuda, Yukuo Konishi, Takashi Kusaka
Organizer
The 13th Asian and Oceanian Congress of Child Neurology
Place of Presentation
Taiwan
Year and Date
2015-05-14
Related Report
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[Presentation] Relationship between early changes in cerebral blood volume and electrocortical activity after hypoxic-ischemic insult in newborn piglets2013
Author(s)
Nakamura Shinji, Kusaka Takashi, Koyano Kosuke, Miki Takanori, Uno Masaki, Jinnai Wataru, Yasuda Saneyuki, Nakamura Makoto, Okada Hitoshi, Isobe Kenichi, Itoh Susumu.
Organizer
ASPR-PSM 2013 Joint scientific Meeting 9th ASPR Congress & 20th PSM Annual Congress
Place of Presentation
Borneo Convention Centre Kuching, Sarawak, Malaysia
Related Report
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[Presentation] Relationship between cerebral blood volume and cortical erectrical activity during hypothermia in piglet asphyxia model2013
Author(s)
Jinnai Wataru, Kusaka Takashi, Wakabayashi Takayuki, Sugino Masashiro, Kunikata Jun, Nakamura Shinji, Koyano Kosuke, Ueno Masaki, Miki Takanori, Nakamura Makoto, Yasuda Saneyuki, Isobe Kenichi, Itoh Susumu.
Organizer
ASPR-PSM 2013 Joint scientific Meeting 9th ASPR Congress & 20th PSM Annual Congress
Place of Presentation
Borneo Convention Centre Kuching, Sarawak, Malaysia
Related Report
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[Presentation] Influence of a free radical scavenger on neuronal damage in a newborn piglet hypoxic-ischemic model.2013
Author(s)
Kusaka Takashi, Nakamura Shinji, Koyano Kosuke, Jinnai Wataru, Nakamura Makoto, Yasuda Saneyuki, Ueno Masaki, Miki Takanori, Itoh Susumu.
Organizer
ASPR-PSM 2013 Joint scientific Meeting 9th ASPR Congress & 20th PSM Annual Congress
Place of Presentation
Borneo Convention Centre Kuching, Sarawak, Malaysia
Related Report
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[Presentation] Relationship between interoptode distance and optical pathlength factor in infants assessed by near-infrared diffuse optical tomography.2013
Author(s)
Kusaka Takashi, Nakamura Shinji, Koyano Kosuke, Yasuda Saneyuki, Okawa Shinpei, Tanikawa Yukari, Feng Gao, Sato Chie, Hoshi Yoko, Yamada Yukio, Itoh Susumu.
Organizer
ASPR-PSM 2013 Joint scientific Meeting 9th ASPR Congress & 20th PSM Annual Congress
Place of Presentation
Borneo Convention Centre Kuching, Sarawak, Malaysia
Related Report
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[Presentation] Evaluation between pathological and aEEG scoring after hypoxic-ischemic insult in newborn piglet model.2013
Author(s)
Nakamura M, Nakamura S, Koyano K, Jinnai W, Kunikata J, Yasuda S, Miki T, Ueno M, Kusaka T, Isobe K, Itoh S.
Organizer
ASPR-PSM 2013 Joint scientific Meeting 9th ASPR Congress & 20th PSM Annual Congress
Place of Presentation
Borneo Convention Centre Kuching, Sarawak, Malaysia
Related Report
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