The research for hypoxic-ischemic intestinal injury in neonate

• Project/Area Number: 25461646
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kagawa University
• Principal Investigator: Kubo Hiroyuki 香川大学, 医学部, 助教 (30564116)
• Co-Investigator(Kenkyū-buntansha): SHIMONO Ryuichi 香川大学, 医学部 小児外科, 准教授 (60404521)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 新生児 / 低酸素性虚血性脳症 / 肝障害 / 脂肪滴 / 低体温治療 / 新生仔豚 / 低酸素負荷 / 臓器障害 / 低酸素虚血性脳症 / 肝臓 / 新生児仮死 / 豚

Outline of Final Research Achievements

Neonatal hypoxic-ischemic encephalopathy(HIE) affects not only brain per se but also liver. The HIE-induced liver injury is expressed by micro-lipid droplet accumulation in the cytoplasm of hepatocytes mainly in the periportal zone, and the accumulation is suppressed by therapeutic hypothermia. We consider that these results contribute to the clarification of pathology of HIE-induced liver injury and the establishment of treatment for neonatal HIE.

Research Products

• [Presentation] 新生仔豚を用いた新生児低酸素性虚血性脳症モデルにおける肝障害の病理組織学的検討 (2015)
  • Author(s): 久保裕之
  • Organizer: 第51回日本周産期新生児医学会
  • Place of Presentation: 福岡
  • Year and Date: 2015-07-12
• [Presentation] 新生仔豚を用いた新生児低酸素性虚血性脳症モデルにおける肝障害の病理組織学的検討 (2015)
  • Author(s): 久保裕之
  • Organizer: 第51回周産期新生児医学会
  • Place of Presentation: 福岡
  • Year and Date: 2015-07-10 – 2015-07-12
• [Presentation] 新生仔豚を用いた新生児低酸素性虚血性脳症モデルにおける肝障害の病理組織学的検討 (2015)
  • Author(s): 久保裕之
  • Organizer: 第23回肝病態生理研究会
  • Place of Presentation: 熊本
  • Year and Date: 2015-05-20
• [Presentation] 新生仔豚を用いた新生児低酸素性虚血性脳症モデルにおける肝障害の病理組織学的検討 (2015)
  • Author(s): 久保裕之
  • Organizer: 第23回肝病態生理研究会
  • Place of Presentation: 熊本県
  • Year and Date: 2015-05-20