| Project/Area Number |
25461657
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Osaka Medical College |
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Principal Investigator |
Ogihara Tohru 大阪医科大学, 医学部, 准教授 (00211128)
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| Co-Investigator(Kenkyū-buntansha) |
長谷川 昌史 大阪医科大学, 医学部, 助教 (80388264)
山岡 繁夫 大阪医科大学, 医学部, 助教 (90434779)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | BPD / resolvin / bleomycin / 新生児慢性肺疾患 / 炎症収束性メディエーター / Bleomycin肺線維症モデル / 炎症収束性脂質メディエーター / lipoxin / 酸化ストレスマーカー |
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| Outline of Final Research Achievements |
It has long been thought that the resolution of inflammation is a passive process associated with a shift in leukocyte population, neutrophils to macrophages, and a clearance of proinflammatory cytokines. Recently, it has been gradually revealed that the resolution of inflammation is an active process governed by several pro-resolving mediators such as fatty acid derivatives including lipoxine, resolvin, and protectin. The precise pathogenesis of BPD is not clearly understood, however, prolonged, non-resolving inflammation may be deeply correlated to the onset and severity of BPD. We hypothesized that the administration of pro-resolving lipid mediators may induce early termination of inflammation and mitigate the severity of BPD. In this study, we used a model of bleomycin-induced BPD in neonatal rats and confirmed that resolvin, one of the pro-resolving lipid mediators, effectively prevented alveolar maturation arrest.
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