| Project/Area Number |
25461659
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Embryonic/Neonatal medicine
|
|---|
| Research Institution | Institute for Developmental Research, Aichi Human Service Center |
|---|
Principal Investigator |
NAKANISHI KEIKO 愛知県心身障害者コロニー発達障害研究所, 周生期学部, 主任研究員 (50280813)
|
|---|
| Research Collaborator |
SATO YOSHIAKI 名古屋大学, 医学部附属病院・総合周産母子医療センター・新生児科, 講師
ITO MIHARU 名古屋大学, 医学部附属病院・総合周産母子医療センター・新生児科, 特任助教
HIGASHI YUJIRO 愛知県心身障害者コロニー発達障害研究所, 周生期学部, 部長
MIZUTANI YUKA 愛知県心身障害者コロニー発達障害研究所, 周生期学部, 助手
HIRAKAWA AKIHIRO 名古屋大学, 医学部附属病院・先端医療・臨床研究支援センター, 講師
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 臍帯血幹細胞 / 新生児低酸素性虚血性脳症 / 移植再生医療 |
|---|
| Outline of Final Research Achievements |
Mononuclear cells isolated from rat umbilical cord blood were expanded (stem cell enriched-umbilical cord blood cells; SCE-UCBCs) and they were administered intraperitoneally to neonatal hypoxic-ischemic encephalopathy (HIE) model of rats. Administration of SCE-UCBCs increased the residual brain volume and decreased the accumulation of activated microglia to lesion site. These results indicate that UCBCs could ameliorate HI injury, possibly through an endogenous response.
|
