the pathogenic mechanisms of EGFR inhibitor-induced rash and establishment of system for constructing medical treatment
| Project/Area Number |
25461666
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Shinshu University |
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Principal Investigator |
UHARA Hisashi 信州大学, 学術研究院医学系, 准教授 (40201355)
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| Co-Investigator(Kenkyū-buntansha) |
ASHIDA Atsuko 信州大学, 学術研究院医学系, 助教 (00596786)
OKUYAMA Ryuhei 信州大学, 学術研究院医学系, 教授 (80292332)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | EGFR阻害剤 / ざ瘡様皮疹 / 脂腺細胞 / SEB-1 / PPARγ / NFkappaB / COX-2 / エルロチニブ / NFκB / ゲフィチニブ / 皮疹 / 痤瘡様皮疹 / サイトカイン / PPAR |
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| Outline of Final Research Achievements |
We investigated the pathogenic mechanisms of EGFR inhibitor-induced papulopustular rash development, using cultured human sebocytes, SEB-1. Blockade of EGFR led to TNFα induction, which was associated with sebaceous differentiation. EGFR inhibitor-induced TNFα expression was involves with PPARγ, COX-2 and NFκB; thus, inhibition of these molecules may attenuate inflammation of papulopustular rash.
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Report
(4 results)
Research Products
(4 results)
