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Mechanism of photo-skin-carcinogenesis induced by ultraviolet/reactive oxygen species/DNA damage; how associated with inflammatory response?

Research Project

Project/Area Number 25461668
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionKobe University

Principal Investigator

Kunisada Makoto  神戸大学, 医学(系)研究科(研究院), 助教 (80566969)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords紫外線発がん / DNA損傷 / 活性酸素 / Ogg1マウス / スピルリナ / 炎症反応 / 紫外線皮膚発がん / 炎症 / p53 / 紫外線皮膚発癌 / 紫外線発癌 / 色素性乾皮症
Outline of Final Research Achievements

We have previously shown that Ogg1 enzyme, repair DNA damage caused by reactive oxygen species by UVB has an important role for developing UV-induced skin cancers. Among up-regulated genes in Ogg1 knock-out mice by UVB, inflammatory response pathway genes are key gene group in highly susceptible to skin tumors. We this time studied precise mechanism using isolated fibroblasts from Ogg1 mice and found that Cxcl1, chemokine gene and Versican, proteoglycan sulfate coding gene dramatically up-regulated in Ogg1 knock-out mice derived fibroblasts after UVB exposure. Furthermore, those two genes were regulating each other with validation using siRNA system. Another study was about the anti-photo-carcinogenesis effects on mice by algae Spirulina administration. Spirulina showed anti-inflammatory response after UVB exposure and inhibit of phosphorylation of signal protein regarding UVB irradiation-associated protein of Ogg1 mice as well as wild type counterpart mice.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Invited: 4 results)

  • [Journal Article] Detection of UV-induced cyclobutane pyrimidine dimers by near-infrared spectroscopy and aquaphotomics2015

    • Author(s)
      Goto N, Bazar C, Kovacs Z, Kunisada M, Morita H, Kizaki S, Sugiyama H, Tsenkova R, Nishigori C
    • Journal Title

      Sci Rep

      Volume: Jul 2;5 Issue: 1 Pages: 11808-11808

    • DOI

      10.1038/srep11808

    • NAID

      120005822771

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Inhibitory effects of dietary Spirulina platensis on UVB induced skin inflammatory responses and carcinogenesis.2014

    • Author(s)
      Yogianti, F., Kunisada, M., Nakano, E., Ono, R., Sakumi, K., Oka, S., Nakabeppu, Y., and Nishigori, C.
    • Journal Title

      J Invest Dermatol

      Volume: N/A Issue: 10 Pages: 2610-2619

    • DOI

      10.1038/jid.2014.188

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effects of dietary Spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis2014

    • Author(s)
      Yogianti F, Kunisada M, Nakano E, Ono R, Sakumi K, Oka S, Nakabeppu Y, Nishigori C
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 00

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Molecular mechanisms of UVB carcinogenesis2014

    • Author(s)
      Makoto Kunisada
    • Organizer
      XV WORLD CONGRESS ON CANCERS OF THE SKIN
    • Place of Presentation
      エジンバラ、英国
    • Year and Date
      2014-09-03 – 2014-09-06
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Spirulina platensisにおける抗炎症反応を介してのUVB長期照射によるマウス皮膚発癌抑制作用の検討2014

    • Author(s)
      国定 充
    • Organizer
      日本光医学・光生物学会
    • Place of Presentation
      浜松市
    • Year and Date
      2014-07-25 – 2014-07-26
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] (奨励賞講演)Spirulina platensisにおける抗炎症反応を介してのUVB長期照射によるマウス皮膚発癌抑制作用の検討2014

    • Author(s)
      国定 充、Flandiana Yogianti、小野竜介、作見邦彦、岡素雅子、中別府雄作、錦織千佳子
    • Organizer
      第36回日本光医学・光生物学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Molecular mechanisms of UVB carcinogenesis2014

    • Author(s)
      国定 充
    • Organizer
      World Congress of Cancers of the Skin at the Edinburgh
    • Place of Presentation
      エジンバラ
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Spirulina platensisにおける抗炎症反応を介してのUVB長期照射によるマウス皮膚発癌抑制作用の検討2013

    • Author(s)
      国定 充、Flandiana Yogianti、小野竜介、作見邦彦、岡素雅子、中別府雄作、錦織千佳子
    • Organizer
      第35回日本光医学・光生物学会
    • Place of Presentation
      浜松
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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