The pathogenesis of palmoplantar pustulosis and the eccrine sweat innate immune system failure

• Project/Area Number: 25461670
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Ehime University
• Principal Investigator: Murakami Masamoto 愛媛大学, 医学部附属病院, 講師 (20278302)
• Co-Investigator(Renkei-kenkyūsha): Shirakata Yuji 愛媛大学, 医学部附属病院, 准教授
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 掌蹠膿疱症 / 抗菌ペプチド / エクリン汗 / 自然免疫 / 3次元培養皮膚

Outline of Final Research Achievements

Based on the reported finding that eccrine gland of the lesion could be involved in the pathogenesis of palmoplantar pustulosis (PPP), we searched suspected materials which contributed to the pathogenesis of PPP in lesion vesicles. As one of the candidates, hCAP18/LL37 expression in the vesicles was nominated, and we showed that it contributed to subsequent lesion inflammation with upregulation of inflammatory cytokines. According to this finding, PPP could be regarded as a disease which was caused by abnormal antimicrobial expression, innate immune system failure.

Research Products

• [Journal Article] 汗と湿疹 (2015)
  • Author(s): 村上正基
  • Journal Title: アレルギー・免疫 Volume: 22 Pages: 63-68
  • Peer Reviewed
• [Journal Article] Vesicular LL-37 contributes to inflammation of the lesional skin of palmoplantar pustulosis. (2014)
  • Author(s): Murakami M, Kaneko T, Nakatsuji T, Kameda K, Okazaki H, Dai X, Hanakawa Y, Tohyama M, Ishida-Yamamoto A, Sayama K.
  • Journal Title: PLoS One. Volume: 9 Issue: 10 Pages: 304-311
  • DOI: 10.1371/journal.pone.0110677
  • Peer Reviewed / Open Access
• [Presentation] Vesicular LL-37 contributes to inflammation of the lesional skin of palmoplantar pustulosis. (2014)
  • Author(s): 18.Murakami M, Kaneko T, Nakatsuji T, Kameda K, Hanakawa Y, Tohyama M, Ishida-Yamamoto A, Sayama K.
  • Organizer: 44th Annual ESDR Meeting
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2014-09-10 – 2014-09-13
• [Presentation] Human cathelicidin (hCAP18/LL37) in pustules contributes to the pathogenesis of palmoplantar pustulosis (2013)
  • Author(s): Murakami M, Okazaki H, Shirakata Y, Morhenn VB, Gallo RL, Kaneko T, Ishida-Yamamoto A, Iizuka H, Sayama K.
  • Organizer: International Investigative Dermatology Meeting
  • Place of Presentation: Edingburg, Scotland