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The effect of vorinostat on skin fibrosis and lung fibrosis of systemic sclerosis mouse model

Research Project

Project/Area Number 25461672
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionNagasaki University

Principal Investigator

OGAWA Fumihide  長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (10333519)

Co-Investigator(Kenkyū-buntansha) KUWATSUKA Yutaka  長崎大学, 医歯薬学総合研究科(医学系), 助教 (90437864)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords細胞外マトリックス / 全身性強皮症 / マウスモデル / vorinostat / HDAC阻害薬
Outline of Final Research Achievements

Systemic sclerosis (SSc) is connective tissue disorder characterized by severe fibrosis of the skin and various internal organs. Tight skin (TSK/+) mouse is a putative murine model of SSc characterized by excessive collagen deposition in skin. Vorinostat, a kind of histone deacetylase inhibitor, was injected subcutaneously into the back of the TSK/+ and wild type mice. As a result, vorinostat could not decrease the development of TSK mouse skin fibrosis. We examined the suitable concentration of the vorinostat in vitro by using human skin fibroblasts of SSc or normal human skin. However, mRNA expressions of type I collagen or fibrogenic cytokines were not markedly attenuated by vorinostat administration. These results suggest that vorinostat have little specificity on the SSc skin fibrosis. Also, these result may reflect the fact that vorinostat may have little effect on the HDAC inhibiton relative to other HDAC inhibitors.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2016 2014 2013

All Journal Article (8 results) (of which Peer Reviewed: 3 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] 前額部に紅斑局面、体幹四肢に丘疹・紅斑を呈したIgG4関連疾患の特異疹の1例2016

    • Author(s)
      東 美智子, 東 江里夏, 芦田美輪, 小川文秀, 林 徳真吉, 宇谷厚志
    • Journal Title

      西日本皮膚科

      Volume: 78 Pages: 24-28

    • NAID

      130005152131

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【症例解説】化学療法と2度の骨髄移植により長期寛解を維持している芽球性形成細胞様樹状細胞腫の1例2016

    • Author(s)
      池原 進, 鍬塚 大, 小川文秀, 牧山純也, 新野大介, 大島孝一, 宇谷厚志
    • Journal Title

      皮膚科の臨床

      Volume: 58 Pages: 165-166

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 化学療法と2度の骨髄移植により長期寛解を維持している芽球性形成細胞様樹状細胞腫の1例2016

    • Author(s)
      池原 進, 鍬塚 大, 小川文秀, 牧山純也, 新野大介, 大島孝一, 宇谷厚志
    • Journal Title

      皮膚科の臨床

      Volume: 58 Pages: 271-274

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Yusho patients show increased serum IL-17, IL-23, IL-1beta, and TNFalpha levels more than 40 years after accidental polychlorinated biphenyl poisoning.2014

    • Author(s)
      Kuwatsuka Y., Shimizu K., Akiyama Y., Koike Y., Ogawa F., Furue M., Utani A.
    • Journal Title

      J Immunotoxicol

      Volume: 11 Issue: 3 Pages: 246-249

    • DOI

      10.3109/1547691x.2013.835890

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Autoantibodies to small ubiquitin-like modifier activating enzymes in Japanese patients with dermatomyositis: comparison with a UK Caucasian cohort.2013

    • Author(s)
      Fujimoto M
    • Journal Title

      Ann Rheum Dis

      Volume: 72 Issue: 1 Pages: 151-153

    • DOI

      10.1136/annrheumdis-2012-201736

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 全身性強皮症・限局性強皮症の皮膚病変2013

    • Author(s)
      小川文秀
    • Journal Title

      長崎市医師会報

      Volume: 47 Pages: 21-24

    • Related Report
      2013 Research-status Report
  • [Journal Article] 本邦の強皮症早期重症例の経過に関する多施設共同研究-血清中の接着分子濃度の予後の指標としての評価-2013

    • Author(s)
      長谷川稔, 浅野善英, 石川治, 尹浩信, 遠藤平仁, 小川文秀, 川口鎮司, 桑名正隆, 後藤大輔, 高橋裕樹, 田中住明, 藤本学, 佐藤伸一, 竹原和彦
    • Journal Title

      強皮症における病因解明と根治的治療法の開発 (厚生労働科学研究費補助金:難治性疾患克服研究事業) 平成24年度総括・分担研究報告書

      Volume: - Pages: 15-22

    • Related Report
      2013 Research-status Report
  • [Journal Article] 全身性強皮症に合併する逆流性食道炎に対するエソメプラゾールの有用性2013

    • Author(s)
      小川文秀
    • Journal Title

      強皮症における病因解明と根治的治療法の開発 (厚生労働科学研究費補助金:難治性疾患克服研究事業) 平成24年度総括・分担研究報告書

      Volume: - Pages: 180-182

    • Related Report
      2013 Research-status Report
  • [Presentation] 【教育講演36. 創傷・熱傷ガイドライン-第1版の課題と改訂に向けた取り組み】 膠原病・血管炎に伴う皮膚潰瘍診療ガイドラインについて2013

    • Author(s)
      小川文秀、浅野善英、石井貴之、川上民裕、小寺雅也、藤本学
    • Organizer
      第112回日本皮膚科学会総会
    • Place of Presentation
      横浜市・パシフィコ横浜
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Pazopanibが著効した血管肉腫の1例2013

    • Author(s)
      冨田元、鍬塚大、小池雄太、浅井幸、小川文秀、谷岡未樹、宇谷厚志
    • Organizer
      第29回日本皮膚悪性腫瘍学会学術大会
    • Place of Presentation
      甲府市・甲府富士屋ホテル
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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