Wound healing in focusing extracellular matrices
Project/Area Number |
25461673
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
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Research Institution | Nagasaki University |
Principal Investigator |
UTANI Atsushi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (10292707)
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Co-Investigator(Kenkyū-buntansha) |
KUWATSUKA Yutaka 長崎大学, 医歯薬学総合研究科(医学系), 助教 (90437864)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 細胞外マトリックス / 創傷治癒 / バーシカン / トレース / トランスジェニックマウス |
Outline of Final Research Achievements |
In this study, we focused on a versican (VCAN), a proteoglycan that has chondroitin sulfates chains as glycosaminoglycans. We immunohistochemically found its transient expression in the wound during 3-7 days after wounding on the mouse skin. Furthermore, we made VCAN-promoter-Cre transgenic mouse and obtained VCAN-Cre;ROSA26R mice. Trace experiments with this moice revealed X-gal staining-positive cells were appeared in the wound during 3 to 5 days after wounding. Based on these findings, transient presence of VCAN and its producing cells in the wound may have an essential role for cell migration other than a role as structural components.
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Report
(4 results)
Research Products
(81 results)
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[Journal Article] Postoperative gluteal skin damage associated with latent development of gluteal muscle damage2016
Author(s)
Hattori Y, Ikeuchi T, Kuroda Y, Matsugi K, Minami S, Higuchi T, Zaima M, Ishitoya S, Yamauchi C, Onishi H, Kawamura J, Kitoh K, Oshiro O, Yamamoto Y, Utani A, Hattori N
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Journal Title
J Dermatol
Volume: in press
Issue: 5
Pages: 547-552
DOI
Related Report
Peer Reviewed
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[Journal Article] A CASE OF PSEUDOXANTHOMA ELASTICUM WITH MASSIVE GASTRIC HEMORRHAGE AFTER ENDOSCOPIC BIOPSY2014
Author(s)
三長孝輔, 山下幸孝, 宇谷厚志, 谷口洋平, 幡丸景一, 中谷泰樹, 赤松拓司, 瀬田剛史, 浦井俊二, 上野山義人
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Journal Title
GASTROENTEROLOGICAL ENDOSCOPY
Volume: 56
Issue: 5
Pages: 1756-1762
DOI
NAID
ISSN
0387-1207, 1884-5738
Related Report
Peer Reviewed
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[Presentation] Profile of upregulated molecules in keloids2015
Author(s)
Asai M, Kashiyama K, Kuwatsuka Y, Kiyohara T, Okubo Y, Utani A
Organizer
The 40th Annual Meeting of the Japanese Society for Investigative Dermatology
Place of Presentation
岡山コンベンションセンター(岡山県・岡山市)
Year and Date
2015-12-11
Related Report
Int'l Joint Research
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[Presentation] 中年男性に生じた浮腫性硬化症2015
Author(s)
村山直也、鍬塚大、大久保佑美、小池雄太、宇谷厚志
Organizer
第66回日本皮膚科学会中部支部学術大会
Place of Presentation
神戸国際会議場(兵庫県・神戸市)
Year and Date
2015-10-31
Related Report
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[Presentation] 真皮マトリックスの遺伝性疾患2015
Author(s)
宇谷厚志
Organizer
第265回日本皮膚科学会岡山地方会
Place of Presentation
岡山コンベンションセンター(岡山県・岡山市)
Year and Date
2015-05-16
Related Report
Invited
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