| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
In this study, we focused on a versican (VCAN), a proteoglycan that has chondroitin sulfates chains as glycosaminoglycans. We immunohistochemically found its transient expression in the wound during 3-7 days after wounding on the mouse skin. Furthermore, we made VCAN-promoter-Cre transgenic mouse and obtained VCAN-Cre;ROSA26R mice. Trace experiments with this moice revealed X-gal staining-positive cells were appeared in the wound during 3 to 5 days after wounding. Based on these findings, transient presence of VCAN and its producing cells in the wound may have an essential role for cell migration other than a role as structural components.
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