| Project/Area Number |
25461674
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
Asai Jun 京都府立医科大学, 医学(系)研究科(研究院), 助教 (50438222)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KATOH Norito 京都府立医科大学, 医学研究科, 教授 (30244578)
TAKENAKA Hideya 京都府立医科大学, 医学研究科, 准教授 (80254358)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HIRAKAWA Satoshi 浜松医科大学, 医学部, 准教授 (50419511)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 創傷治癒 / 表皮細胞 / ポドプラニン / 皮膚癌 / 悪性黒色腫 |
|---|
| Outline of Final Research Achievements |
In this study, we evaluated the functional roles of podoplanin in keratinocytes in normal and pathological conditions, especially wound healing and malignant tumor. In wound healing, podoplanin upregulation was observed at the keratinocytes at wound edge. Podoplanin mediated keratinocytes proliferation and motility which resulted in accelerating wound healing. In Extramammary Paget's disease, podoplanin expression was observed at the site of invasion. Podoplanin expression on keratinocytes could predict agressive behavior of Extramammary Paget's disease.
|
