Evaluation of functional roles of podoplanin in skin

• Project/Area Number: 25461674
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Asai Jun 京都府立医科大学, 医学(系)研究科(研究院), 助教 (50438222)
• Co-Investigator(Kenkyū-buntansha): KATOH Norito 京都府立医科大学, 医学研究科, 教授 (30244578) ; TAKENAKA Hideya 京都府立医科大学, 医学研究科, 准教授 (80254358)
• Co-Investigator(Renkei-kenkyūsha): HIRAKAWA Satoshi 浜松医科大学, 医学部, 准教授 (50419511)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 創傷治癒 / 表皮細胞 / ポドプラニン / 皮膚癌 / 悪性黒色腫

Outline of Final Research Achievements

In this study, we evaluated the functional roles of podoplanin in keratinocytes in normal and pathological conditions, especially wound healing and malignant tumor. In wound healing, podoplanin upregulation was observed at the keratinocytes at wound edge. Podoplanin mediated keratinocytes proliferation and motility which resulted in accelerating wound healing. In Extramammary Paget's disease, podoplanin expression was observed at the site of invasion. Podoplanin expression on keratinocytes could predict agressive behavior of Extramammary Paget's disease.

Research Products

• [Journal Article] Platelets regulate the migration of keratinocytes via podoplanin/CLEC-2 signaling during cutaneous wound healing in mice. (2016)
  • Author(s): Asai J, Hirakawa S, Sakabe J, Kishida T, Nakamura N, Takenaka H, Mazda O, Urano T, Suzuki-Inoue K, Tokura Y, Katoh N.
  • Journal Title: Am J Pathol Volume: 186 Issue: 1 Pages: 101-108
  • DOI: 10.1016/j.ajpath.2015.09.007
  • Peer Reviewed / Open Access
• [Journal Article] Podoplanin expression in cancer-associated fibroblasts predicts aggressive behavior in melanoma. (2014)
  • Author(s): Kan S, Konishi E, Arita T, Ikemoto C, Takenaka H, Yanagisawa A, Katoh N, Asai J.
  • Journal Title: J Cutan Pathol. Volume: 41 Issue: 7 Pages: 561-567
  • DOI: 10.1111/cup.12322
  • Peer Reviewed
• [Presentation] Podoplanin expression in peritumorial keratinocytes predicts aggressive behavior in extramammary Paget`s disease. (2015)
  • Author(s): 1. Cho Z, Asai J, Konishi E, Arita T, Takenaka H, Yanagisawa A, Katoh N.
  • Organizer: 45th Annual ESDR Meeting
  • Place of Presentation: Rotterdam, The Netherlands
  • Year and Date: 2015-09-09
  • Int'l Joint Research
• [Presentation] Platelets inhibit keratinocyte migration and proliferation by downregulation of podoplanin. (2013)
  • Author(s): 1. Jun Asai, Satoshi Hirakawa, Jun-ichi Sakabe, Hideya Takenaka, Tetsumei Urano, Katsue Suzuki-Inoue, Yoshiki Tokura, Norito Katoh
  • Organizer: International Investigative Dermatology
  • Place of Presentation: Edinburgh, Scotland