Selection of biomarkers for the evaluation of therapeutic efficacy of severe cutaneous adverse drug reactions
Project/Area Number |
25461676
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
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Research Institution | Kyorin University |
Principal Investigator |
KANO Yoko 杏林大学, 医学部, 客員教授 (20142416)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | Stevens-Johnson症候群 / 中毒性表皮壊死症 / 薬剤性過敏症症候群 |
Outline of Final Research Achievements |
There have been no biomarkers found which can predicting progression to severe cutaneous adverse drug reactions (SCARs). Therefore, there is an urgent need for reliable and standard laboratory tests for identifying patients at higher risk of developing SCARs. A variety of cytokines/chemokines in the serum in patients who presented with clinical symptoms suggestive of SCARs were retrospectively measured using multiplex biometric immunoassay. Our results showed that several biomarkers altered in combinations depending on the clinical type of SCARs such as Stevens-Johnson syndrome and toxic epidermal necrolysis, although each biomarker was not sufficiently sensitive or specific on its own. The evaluation of these markers in combinations could increase the diagnostic and prognostic utility for the prediction of SCARs. Furthermore, the measurements of these selected markers at the initial stage could contribute to the appropriate selection of treatment modalities for SCARs.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Efficacy of additional i.v. immunoglobulin to steroid therapy in Stevens-Johnson syndrome and toxic epidermal necrolysis.2015
Author(s)
Aihara M, Kano Y, Fujita H, Kambara T, Matsukura S, Katayama I, Azukizawa H, Miyachi Y, Endo Y, Asada H, Miyagawa F, Morita E, Kaneko S, Abe R, Ochiai T, Sueki H, Watanabe H, Nagao K, Aoyama Y, Sayama K, Hashimoto K, Shiohara T; SJS/TEN Study Group.
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Journal Title
J Dermatol
Volume: 42
Issue: 8
Pages: 768-777
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Sequelae in 145 patients with drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms: Survey conducted by the Asian Research Committee on Severe Cutaneous Adverse Reactions (ASCAR)2015
Author(s)
Kano Y, Tohyama M, Aihara M, Matsukura S, Watanabe H, Sueki H, Iijima M, Morita E, Niihara H, Asada H, Kabashima K, Azukizawa H, Hashizume H, Nagao K, Takahashi H, Abe R, Sotozono C, Kurosawa M, Aoyama Y, Chu CY, Chung WH, Shiohara T
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Journal Title
Journal of Dermatology
Volume: 42
Issue: 3
Pages: 276-282
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Elevated serum thymus and activation-regulated chemokine (TARC/CCL17) relates to reactivation of human herpesvirus 6 in drug reactions with eosinophilia and systemic symptoms (DRESS)/ drug-induced hypersensitivity syndrome (DIHS).2014
Author(s)
Ogawa K, Morito H, Hasegawa A, Miyagawa F, Kobayashi N, Watanabe H, Sueki H, Tohyama M, Hashimoto K, Kano Y, Shiohara T, Ito K, Fujita H, Aihara M, Asada H
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Journal Title
Br J Dermatol
Volume: -
Issue: 2
Pages: 425-427
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 人工透析患者に生じた多発性固定薬疹の1例2014
Author(s)
佐藤洋平, 堀江千穂, 平原和久, 水川良子, 狩野葉子, 塩原哲夫
Organizer
第113回日本皮膚科学会総会
Place of Presentation
国立京都国際会館(京都市・左京区)
Year and Date
2014-05-30 – 2014-06-01
Related Report
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