Serological and genetical study in Japanese dermatitis herpetiformis

• Project/Area Number: 25461678
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kurume University
• Principal Investigator: OHATA Chika 久留米大学, 医学部, 准教授 (70362712)
• Co-Investigator(Kenkyū-buntansha): HASHIMOTO Takashi 久留米大学, 皮膚細胞生物学研究所, 教授 (20129597)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ジューリング疱疹状皮膚炎 / 自己免疫性水疱症 / IgA / 表皮トランスグルタミナーゼ / 組織トランスグルタミナーゼ / グルテン / 直接蛍光抗体法 / HLA-DQ2, DQ8 / HLA-DQ2 / HLA-DQ8 / HLA-DQA1 / 本邦 / HLA-DR9 / 自己抗体

Outline of Final Research Achievements

Dermatitis herpetiformis (DH) is an extremely pruritic bullous disease, and it preferentially affects Caucasians rather than Japanese. Although gluten sensitivity is considered to develop DH in Caucasian patients, Japanese patients with DH rarely have gluten sensitivity. In this study we found that no Japanese DH patients had HLA-DQ2, and only one-third of Japanese DH patients had HLA-DQ8, despite the fact that almost all Caucasian DH patients bear HLA-DQ2 or -DQ8. Pathogenic autoantibodies, anti-epidermal transglutaminase antibodies, were detected in only two-thirds of Japanese DH patients. This study suggested the possible existence of different cause other than gluten sensitivity in Japanese DH patients.

Research Products

• [Journal Article] Brown macule on the waist. (2016)
  • Author(s): Ohata C
  • Journal Title: Cutis Volume: 97 Pages: 169-172
  • Peer Reviewed
• [Journal Article] Unique characteristics in Japanese dermatitis herpetiformis. (2016)
  • Author(s): Ohata C, Ishii N, Niizeki H, Shimomura Y, Furumura M, Inoko H, Mitsunaga S, Saiki M, Shigeta M, Fujiwara S, Yamakawa K, Kobayashi S, Kamata M, Inaba M, Ito T, Uhara H, Watanabe R, Ohtoshi S, Ohashi T, Tanaka T, Suzuki M, Sitaru C, Karpati S, Zone JJ, Hashimoto T
  • Journal Title: Br J Dermatol Volume: 174 Issue: 1 Pages: 180-183
  • DOI: 10.1111/bjd.13965
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Comparative Study of Direct Immunofluorescence in Discoid Lupus Erythematosus and Bullous Pemphigoid. (2016)
  • Author(s): Ohata C, Ohyama B, Nagata H, Furumura M, Nakama T
  • Journal Title: Am J Dermatopathol Volume: 38 Issue: 2 Pages: 121-123
  • DOI: 10.1097/dad.0000000000000387
  • Peer Reviewed
• [Journal Article] Case of concurrence of anti-laminin gamma-1 pemphigoid and scabies. (2015)
  • Author(s): Iijima S, Okazaki Y, Watanabe S, Tsuruta D, Tateishi C, Ishii N, Ohata C, Hashimoto T
  • Journal Title: J Dermatol Volume: 42 Issue: 10 Pages: 1024-1026
  • DOI: 10.1111/1346-8138.13020
  • Peer Reviewed
• [Journal Article] A three-dimensional in vitro culture model of Hailey-Hailey disease. (2015)
  • Author(s): Matsuda M, Hamada T, Numata S, Teye K, Ishii N, Ohata C, Furumura M, Nakama T, Hashimoto T
  • Journal Title: Exp Dermatol Volume: 24 Issue: 10 Pages: 788-789
  • DOI: 10.1111/exd.12777
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Mutation study for 9 genes in 23 unrelated patients with autosomal recessive congenital ichthyosis in Japan and Malaysia. (2015)
  • Author(s): Numata S, Teye K, Krol RP, Karashima T, Fukuda S, Matsuda M, Ishii N, Furumura M, Ohata C, Saminathan SD, Ariffin R, Pramono ZA, Leong KF, Hamada T, Hashimoto T
  • Journal Title: J Dermatol Sci Volume: 78 Issue: 1 Pages: 82-85
  • DOI: 10.1016/j.jdermsci.2015.02.006
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cutaneous Metastasis of Cecal Carcinoma With Epidermotropism. (2015)
  • Author(s): Ohata C, Imamura T, Nakama T
  • Journal Title: Dermatol Surg Volume: 41 Issue: 7 Pages: 854-856
  • DOI: 10.1097/dss.0000000000000381
  • Peer Reviewed
• [Journal Article] Adnexal involvement in bullous pemphigoid. (2015)
  • Author(s): Ohata C, Ishii N, Furumura M, Nakama T
  • Journal Title: J Cutan Pathol Volume: 42 Issue: 8 Pages: 587-590
  • DOI: 10.1111/cup.12520
  • Peer Reviewed
• [Journal Article] Coexistence of autoimmune bullous diseases (AIBDs) and psoriasis: A series of 145 cases. (2015)
  • Author(s): Ohata C, Ishii N, Koga H, Fukuda S, Tateishi C, Tsuruta D, Furumura M, Hashimoto T
  • Journal Title: J Am Acad Dermatol Volume: 73 Issue: 1 Pages: 50-55
  • DOI: 10.1016/j.jaad.2015.03.016
  • Peer Reviewed
• [Journal Article] esicles and pustules on the fingers as an initial manifestation of eosinophilic pustular folliculitis. (2015)
  • Author(s): Ohata C, Nii S, Furumura M, Nakama T
  • Journal Title: J Dermatol Volume: 42 Issue: 9 Pages: 914-915
  • DOI: 10.1111/1346-8138.12946
  • Peer Reviewed
• [Journal Article] Frequent office visits for injections may reduce adalimumab survival rate in patients with psoriasis. (2015)
  • Author(s): Ohata C, Shintani T, Arakawa M, Yoshimura K, Ohyama B, Ishii N, Ono F, Hamada T, Karashima T, Furumura M
  • Journal Title: J Dermatolog Treat Volume: 26 Issue: 4 Pages: 312-313
  • DOI: 10.3109/09546634.2014.962470
  • Peer Reviewed
• [Journal Article] Loss of heterozygosity in a case of glomuvenous malformations. (2015)
  • Author(s): Ohata C, Matsuda M, Hamada T, Shintani T, Muto I, Nagata H, Furumura M, Nakama T
  • Journal Title: J Dermatol Volume: 印刷中 Issue: 6 Pages: 646-647
  • DOI: 10.1111/1346-8138.12849
  • Peer Reviewed
• [Journal Article] Presence of autoimmune regulator and absence of desmoglein 1 in thymoma associated with a pemphigus foliaceus patient. (2015)
  • Author(s): Tsuchisaka, A.
  • Journal Title: Br. J. Dermatol. Volume: 印刷中 Issue: 1 Pages: 268-271
  • DOI: 10.1111/bjd.13617
  • Peer Reviewed
• [Journal Article] Epidermal polymeric immunoglobulin receptors: leads from intraepidermal neutrophilic IgA dermatosis-type IgA pemphigus. (2015)
  • Author(s): Tsuchisaka A, Ishii N, Hamada T, Teye K, Sogame R, Koga H, Tsuruta D, Ohata C, Furumura M, Hashimoto T
  • Journal Title: Exp Dermatol Volume: 24 Issue: 3 Pages: 217-219
  • DOI: 10.1111/exd.12615
  • Peer Reviewed
• [Journal Article] Clinical and immunological profiles of 25 patients with pemphigoid gestationis. (2015)
  • Author(s): Tani N, Kimura Y, Koga H, Kawakami T, Ohata C, Ishii N, Hashimoto T
  • Journal Title: Br J Dermatol Volume: 172 Issue: 1 Pages: 120-129
  • DOI: 10.1111/bjd.13374
  • Peer Reviewed
• [Journal Article] Anti-desmocollin autoantibodies in non-classical pemphigus. (2015)
  • Author(s): Ishii N, Teye K, Fukuda S, Uehara R, Hachiya T, Koga H, Tsuchisaka A, Numata S, Ohyama B, Tateishi C, Tsuruta D, Furumura M, Hattori S, Kawakami T, Ohata C, Hashimoto T
  • Journal Title: Br J Dermatol Volume: 印刷中 Issue: 1 Pages: 59-68
  • DOI: 10.1111/bjd.13711
  • Peer Reviewed
• [Journal Article] A case of bullous pemphigoid associated with psoriasis vulgaris showing Hailey-Hailey disease-like histopathological changes in regenerated epidermis without genomic mutation in ATP2C1 or ATP2A2 gene. (2015)
  • Author(s): Iino Y, Kano T, Adachi F, Suzuki M, Nishikawa R, Ishii N, Ohata C, Furumura M, Hamada T, Hashimoto T
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 29 Issue: 8 Pages: 1646-1648
  • DOI: 10.1111/jdv.12521
  • Peer Reviewed
• [Journal Article] Locations of acantholysis in pemphigus vulgaris and pemphigus foliaceus. (2014)
  • Author(s): Ohata C, Ishii N, Furumura M
  • Journal Title: J Cutan Pathol Volume: 41 Issue: 11 Pages: 880-889
  • DOI: 10.1111/cup.12384
  • Peer Reviewed
• [Journal Article] Molluscum contagiosum with CD30+ cell infiltration in a patient with mycosis fungoides. (2014)
  • Author(s): Ohata C, Fukuda S, Hashikawa K, Ishii N, Hamada T, Nakama T, Furumura M, Tsuruta D, Ohshima K, Hashimoto T
  • Journal Title: Am J Dermatopathol Volume: 36 Issue: 8 Pages: 685-687
  • DOI: 10.1097/dad.0000000000000056
  • Peer Reviewed
• [Journal Article] Hailey-Hailey disease. (2014)
  • Author(s): Ohata C
  • Journal Title: Cutis Volume: 94
  • Peer Reviewed
• [Journal Article] Clinical and immunological profiles in 17 Japanese patients with drug-induced pemphigus studied at Kurume University. (2014)
  • Author(s): Yoshimura K, Ishii N, Hamada T, Abe T, Ono F, Hashikawa K, Fukuda S, Ohyama B, Koga H, Sogame R, Teye K, Ochiai T, Nakajima H, Nakajima K, Iijima S, Kanzaki M, Kojima K, Nagatani T, Fujimoto W, Karashima T, Nakama T, Ohata C, Furumura M, Tsuruta D, Hashimoto T
  • Journal Title: Br J Dermatol Volume: 171 Issue: 3 Pages: 544-553
  • DOI: 10.1111/bjd.12925
  • Peer Reviewed
• [Journal Article] Immunological and Statistical Studies of Anti-BP180 Antibodies in Paraneoplastic Pemphigus (2014)
  • Author(s): Tsuchisaka A, Kawano H, Yasukochi A, Teye K, Ishii N, Koga H, Sogame R, Ohzono A, Krol RP, Kawakami T, Furumura M, Ohata C, Li X, Hashimoto T
  • Journal Title: J Invest Dermatol Volume: 134 Issue: 8 Pages: 2283-2287
  • DOI: 10.1038/jid.2014.151
  • Peer Reviewed
• [Journal Article] Homozygous deletion of six genes including corneodesmosin on chromosome 6p21.3 is associated with generalized peeling skin disease. (2014)
  • Author(s): Teye K, Hamada T, Krol RP, Numata S, Ishii N, Matsuda M, Ohata C, Furumura M, Hashimoto T
  • Journal Title: J Dermatol Sci Volume: 75 Issue: 1 Pages: 36-42
  • DOI: 10.1016/j.jdermsci.2014.04.003
  • Peer Reviewed
• [Journal Article] Characterization of two cases of bullous pemphigoid reactive only with BP230 on Japanese enzyme-linked immunosorbent assays. (2014)
  • Author(s): Sasai S, Nishikawa R, Ohzono A, Hayakawa T, Tsuruta D, Kudoh K, Kikuchi T, Hashiguchi M, Ohata C, Furumura M, Koga H, Ishii N, Hashimoto T
  • Journal Title: Acta Derm Venereol Volume: 94 Issue: 6 Pages: 734-736
  • DOI: 10.2340/00015555-1848
  • Peer Reviewed
• [Journal Article] Adenocarcinoma of Moll's gland with multiple metastases. (2014)
  • Author(s): Saruta H, Ohata C, Muto I, Yoshimura K, Inoue Y, Hamada T, Furumura M, Hashimoto T
  • Journal Title: Eur J Dermatol Volume: 24 Issue: 2 Pages: 269-271
  • DOI: 10.1684/ejd.2014.2296
  • Peer Reviewed
• [Journal Article] B-cell activating factor detected on both naive and memory B cells in bullous pemphigoid. (2014)
  • Author(s): Qian H, Kusuhara M, Li X, Tsuruta D, Tsuchisaka A, Ishii N, Koga H, Hayakawa T, Ohara K, Karashima T, Ohyama B, Ohata C, Furumura M, Hashimoto T
  • Journal Title: Exp Dermatol Volume: 23 Issue: 8 Pages: 596-605
  • DOI: 10.1111/exd.12421
  • Peer Reviewed
• [Journal Article] Late-onset Brooke-Spiegler syndrome with family histories of various cancers. (2014)
  • Author(s): Matsuda M, Ohata C, Hamada T, Oiso N, Tsuruta D, Furumura M, Hashimoto T
  • Journal Title: J Dermatol Volume: 41 Issue: 5 Pages: 454-456
  • DOI: 10.1111/1346-8138.12451
  • Peer Reviewed
• [Journal Article] Mutation-dependent effects on mRNA and protein expressions in cultured keratinocytes of Hailey-Hailey disease. (2014)
  • Author(s): Matsuda M, Hamada T, Numata S, Teye K, Okazawa H, Imafuku S, Ohata C, Furumura M, Hashimoto T
  • Journal Title: Exp Dermatol Volume: 23 Issue: 7 Pages: 514-516
  • DOI: 10.1111/exd.12410
  • Peer Reviewed
• [Journal Article] Human dermal fibroblast migration induced by fibronectin in autocrine and paracrine manners. (2014)
  • Author(s): Li X, Qian H, Ono F, Tsuchisaka A, Krol RP, Ohara K, Hayakawa T, Matsueda S, Sasada T, Ohata C, Furumura M, Hamada T, Hashimoto T
  • Journal Title: Exp Dermatol Volume: 23 Issue: 9 Pages: 682-684
  • DOI: 10.1111/exd.12447
  • Peer Reviewed
• [Journal Article] Mouse bone marrow-derived dendritic cells can phagocytize the Sporothrix schenckii, and mature and activate the immune response by secreting interleukin-12 and presenting antigens to T lymphocytes. (2014)
  • Author(s): Kusuhara M, Qian H, Li X, Tsuruta D, Tsuchisaka A, Ishii N, Ohata C, Furumura M, Hashimoto T
  • Journal Title: J Dermatol Volume: 41 Issue: 5 Pages: 386-392
  • DOI: 10.1111/1346-8138.12472
  • Peer Reviewed
• [Journal Article] Distinct protein expression and activity of transglutaminases found in different epidermal tumors. (2014)
  • Author(s): Karashima T, Furumura M, Ishii N, Ohyama B, Saruta H, Natsuaki Y, Nakama T, Ohata C, Tsuruta D, Hitomi K, Hashimoto T
  • Journal Title: Exp Dermatol Volume: 23 Issue: 6 Pages: 433-435
  • DOI: 10.1111/exd.12418
  • Peer Reviewed
• [Journal Article] Diagnosis of oral mucous membrane pemphigoid by means of combined serologic testing. (2014)
  • Author(s): Hayakawa T, Furumura M, Fukano H, Li X, Ishii N, Hamada T, Ohata C, Tsuruta D, Shimozato K, Hashimoto T
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 117 Issue: 4 Pages: 483-496
  • DOI: 10.1016/j.oooo.2013.12.402
  • Peer Reviewed
• [Journal Article] Antibodies to the amino-terminal domain of desmoglein 1 are retained during transition from pemphigus vulgaris to pemphigus foliaceus. (2014)
  • Author(s): Espana A, Koga H, Suarez-Fernandez R, Ohata C, Ishii N, Irarrazaval I, Teye K, Ohyama B, Hashimoto T
  • Journal Title: Eur J Dermatol Volume: 24 Issue: 2 Pages: 174-179
  • DOI: 10.1684/ejd.2014.2277
  • Peer Reviewed
• [Journal Article] Detection of Autoantibodies to Precursor Proteins of Desmogleins in Sera of a Patient with Bowen Carcinoma (2014)
  • Author(s): Demitsu T, Yamada T, Nakamura S, Kakurai M, Dohmoto T, Kamiya K, Aoyama Y, Iwatsuki K, Yamagami J, Ohyama B, Ohata C, Koga H, Hashimoto T
  • Journal Title: Acta Derm Venereol Volume: 94 Issue: 5 Pages: 601-603
  • DOI: 10.2340/00015555-1776
  • Peer Reviewed
• [Journal Article] Coexistence of pemphigus herpetiformis with IgG antibodies to desmocollin 1 and pemphigoid with IgG antibodies to BP180 C-terminal domain and laminin γ2. (2013)
  • Author(s): Ohata C, Higashi Y, Yamagami J, Koga H, Ishii N, Kanekura T, Furumura M, Hashimoto T
  • Journal Title: JAMA Dermatol Volume: 149 Issue: 4 Pages: 502-504
  • DOI: 10.1001/jamadermatol.2013.1916
  • Peer Reviewed
• [Journal Article] Refractory anti-laminin γ1 pemphigoid with psoriasis vulgaris successfully treated by double-filtration plasmapheresis (2013)
  • Author(s): Ohata C, Fukuda S, Ishii N, Koga H, Hamada T, Furumura M, Hashimoto T
  • Journal Title: Eur J Dermatol Volume: 23 Issue: 5 Pages: 715-716
  • DOI: 10.1684/ejd.2013.2138
  • Peer Reviewed
• [Journal Article] Discoid lupus erythematosus with the presence of a lupus band in the hair follicle basement membrane zone and IgA anti-BP230 autoantibodies (2013)
  • Author(s): Ohata C, Saiki M, Koga H, Ono F, Ohyama B, Ishii N, Hamada T, Tsuruta D, Furumura M, Hashimoto T
  • Journal Title: Eur J Dermatol Volume: 23 Issue: 3 Pages: 414-416
  • DOI: 10.1684/ejd.2013.2026
  • Peer Reviewed
• [Presentation] A clinical and serological study of linear IgA bullous dermatosis. (2016)
  • Author(s): Chika Ohata, Norito Ishii, Hiroshi Koga, Takekuni Nakama
  • Organizer: 4th Annual Meeting of American Academy of Dermatology
  • Place of Presentation: Washington, VA. USA
  • Year and Date: 2016-03-04
  • Int'l Joint Research
• [Presentation] Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma: A rare entity with aggressive clinical behavior and poor prognosis. (2016)
  • Author(s): Chika Ohata, Hiroshi Saruta, Yohei Natsuaki, Koichi Ohshima, Takekuni Nakama
  • Organizer: 19th Joint Meeting of The International Society of Dermatopathology
  • Place of Presentation: Washington, VA. USA
  • Year and Date: 2016-03-02
  • Int'l Joint Research
• [Presentation] Self-assessment course, Case 21: Erythema elevatum diutinum. (2015)
  • Author(s): Chika Ohata
  • Organizer: XXXVI Symposium of the International Society of Dermatopathology
  • Place of Presentation: New Delhi, India
  • Year and Date: 2015-11-19
  • Int'l Joint Research
• [Presentation] 人工流産後も長期間難治であった妊娠性疱疹の血清学的検討 (2015)
  • Author(s): 大畑千佳、荒川正崇、石井文人、名嘉眞武国、橋本隆
  • Organizer: 第37回水疱症研究会
  • Place of Presentation: コラッセ福島（福島県・福島市）
  • Year and Date: 2015-09-26
• [Presentation] インフリキシマブによる肝障害が疑われた尋常性乾癬の1例 (2015)
  • Author(s): 大畑千佳、大山文悟、永田寛、猿田寛、古村南夫、名嘉眞武国
  • Organizer: 第30回日本乾癬学会
  • Place of Presentation: ウェスティンナゴヤキャッスル（愛知県・名古屋市）
  • Year and Date: 2015-09-04
• [Presentation] The impact of biological agents on Japanese patients with psoriasis. (2015)
  • Author(s): Chika Ohata, Bungo Ohyama, Fumitake Ono, Tadashi Karashima, Takahiro Hamada, Norito Ishii, Yohei Natsuaki, Hiroshi Saruta, Michi Gohara, Naomi Tani, Minao Furumura, Takekuni Nakama
  • Organizer: 23rd World Congress of Dermatology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2015-06-08
  • Int'l Joint Research
• [Presentation] Loss of heterozygosity in a case of glomuvenous malformations. (2015)
  • Author(s): Chika Ohata, Mitsuhiro Matsuda, Takahiro Hamada, Kwesi Teye, Sanae Numata, Takako Shintani, Ikko Muto, Minao Furumura, Takekuni Nakama.
  • Organizer: 73rd Annual Meeting of American Academy of Dermatology.
  • Place of Presentation: San Francisco, CA. USA
  • Year and Date: 2015-03-20 – 2015-03-24
• [Presentation] Reappraisal of the histopathological features of bullous pemphigoid. (2015)
  • Author(s): Chika Ohata, Norito Ishii, Minao Furumura, Takekuni Nakama.
  • Organizer: 18th Joint Meeting of The International Society of Dermatopathology.
  • Place of Presentation: San Francisco, CA. USA
  • Year and Date: 2015-03-18 – 2015-03-19
• [Presentation] 久留米大学皮膚科における乾癬患者実態調査2014 (2014)
  • Author(s): 大畑千佳、大山文悟、小野文武、辛島正志、濱田尚宏、石井文人、夏秋洋平、猿田寛、合原みち、谷直実、古村南夫、名嘉眞武国
  • Organizer: 第29回日本乾癬学会
  • Place of Presentation: 高知
  • Year and Date: 2014-09-19 – 2014-09-20
• [Presentation] Expression of desmosomal cadherins in malignant melanoma (2013)
  • Author(s): Chika Ohata
  • Organizer: XXXIV Symposium of the International Society of Dermatopathology, Florence, Italy
  • Place of Presentation: イタリア、フィレンツェ
• [Presentation] 過去18年間に経験した乾癬と自己免疫性水疱症の合併例のまとめ (2013)
  • Author(s): 大畑千佳、古賀浩嗣、古村南夫、橋本隆
  • Organizer: 第35回水疱症研究会
  • Place of Presentation: 大分労働福祉会館ソレイユ
• [Presentation] Clinical, immunological and genetical analysis of Japanese dermatitis herpetiformis
  • Author(s): Chika Ohata
  • Organizer: The 3rd International Mini Symposium on Dermaatology in Kurume
  • Place of Presentation: 久留米大学