| Project/Area Number |
25461678
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kurume University |
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Principal Investigator |
OHATA Chika 久留米大学, 医学部, 准教授 (70362712)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Takashi 久留米大学, 皮膚細胞生物学研究所, 教授 (20129597)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ジューリング疱疹状皮膚炎 / 自己免疫性水疱症 / IgA / 表皮トランスグルタミナーゼ / 組織トランスグルタミナーゼ / グルテン / 直接蛍光抗体法 / HLA-DQ2, DQ8 / HLA-DQ2 / HLA-DQ8 / HLA-DQA1 / 本邦 / HLA-DR9 / 自己抗体 |
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| Outline of Final Research Achievements |
Dermatitis herpetiformis (DH) is an extremely pruritic bullous disease, and it preferentially affects Caucasians rather than Japanese. Although gluten sensitivity is considered to develop DH in Caucasian patients, Japanese patients with DH rarely have gluten sensitivity. In this study we found that no Japanese DH patients had HLA-DQ2, and only one-third of Japanese DH patients had HLA-DQ8, despite the fact that almost all Caucasian DH patients bear HLA-DQ2 or -DQ8. Pathogenic autoantibodies, anti-epidermal transglutaminase antibodies, were detected in only two-thirds of Japanese DH patients. This study suggested the possible existence of different cause other than gluten sensitivity in Japanese DH patients.
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