Development of novel immunotherapy for malignant melanoma by targeting MDSC.
| Project/Area Number |
25461682
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Tohoku University |
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Principal Investigator |
Fujimura Taku 東北大学, 医学(系)研究科(研究院), 助教 (50396496)
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| Co-Investigator(Kenkyū-buntansha) |
Aiba SETSUYA 東北大学, 医学系研究科, 教授 (80159269)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 腫瘍随伴マクロファージ / 制御性T細胞 / MDSC / 悪性黒色腫 / PD-L1 / ケモカイン / 腫瘍随伴性マクロファージ / 腫瘍免疫 / PD-1/ PD-L1 / 免疫療法 / 骨髄由来抑制細胞 / PD-1 |
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| Outline of Final Research Achievements |
Our present study revealed that, not only the expression of PD-L1, but also the production of chemokine is important to modify the immunosuppressive microenvironment in B16F10 melanoma model. In addition, on human M2 macrophages, the expression of PD-L1 could be decreased by the treatment of several immune therapy for metastatic melanoma. We published these data at Oncoimmunology in 2015. Moreover, we further investigated tumor-associated macrophages in the series of skin tumor, including invasive and non-invasive extramammary Paget's disease and mycosis fungicides. These data was published at Journal of Investigative Dermatology and Experimental Dermatology in 2015 and 2016.
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Report
(4 results)
Research Products
(61 results)
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[Journal Article] In vivo imaging demonstrates ATP release from murine keratinocytes and its involvement in cutaneous inflammation after tape-stripping2013
Author(s)
Takahashi, T., Kimura, Y., Niwa, K., Ohmiya, Y., Fujimura, T., Yamasaki, K., and Aiba, S.
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Journal Title
J Invest Dermatol
Volume: 133
Issue: 10
Pages: 2407-15
DOI
Related Report
Peer Reviewed
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