| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
Our present study revealed that, not only the expression of PD-L1, but also the production of chemokine is important to modify the immunosuppressive microenvironment in B16F10 melanoma model. In addition, on human M2 macrophages, the expression of PD-L1 could be decreased by the treatment of several immune therapy for metastatic melanoma. We published these data at Oncoimmunology in 2015. Moreover, we further investigated tumor-associated macrophages in the series of skin tumor, including invasive and non-invasive extramammary Paget's disease and mycosis fungicides. These data was published at Journal of Investigative Dermatology and Experimental Dermatology in 2015 and 2016.
|
