Detection of human papillomaviruses in skin tumors and investigation of the pathgenesis
| Project/Area Number |
25461683
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Gunma University |
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Principal Investigator |
Shimizu Akira 群馬大学, 医学部附属病院, 講師 (70396638)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 皮膚科学 / ヒト乳頭腫ウイルス / 遺伝性疾患 / Human papillomavirus / 皮膚腫瘍 / ボーエン病 / 新規HPVクローニング / 多発性疣贅 / 免疫不全 / human papillomavirus / squamous cell carcinoma / Bowen's disease / condyloma |
|---|
| Outline of Final Research Achievements |
We reported HPV-associated Bowen’s disease and clarified some characteristics. 1. It could be detected in young patient. 2. Nail and anogenital region were mainly affected. 3. Some cases showed longitudinal melanonychia. We have reported a case of HPV type 67 associated Bowen’s disease presenting with longitudinal melanonychia. We further investigated 30 cases of squamous cell carcinoma and detected 2 HPV type 16 associated SCC. They were anogenital SCC and had been developed from bowenoid papulosis. Furthermore, we newly reported a case of keratotic condyloma acuminatum and a pigmented condyloma acuminatum. In the last year, we examined a patient with generalized verrucosis due to GATA2 deficiency. Numerous warts were scattered in the hand and foot. Several HPV types were detected. The mechanism of the susceptibility to HPV is under investigation.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Prognostic significance of L-type amino acid transporter 1 (LAT1) expression in cutaneous melanoma.2015
Author(s)
Shimizu A, Kaira K, Kato M, Yasuda M, Takahashi A, Tominaga H, Oriuchi N, Nagamori S, Kanai Y, Oyama T, Asao T, Ishikawa O.
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Journal Title
Melanoma Res.
Volume: 25
Issue: 5
Pages: 399-405
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Detection of Human Papillomavirus Type 56 in Giant Condyloma Acuminatum.2014
Author(s)
Ishibuchi T, Shimizu A, Kato M, Takeuchi Y, Aoyama K, Yasuda M, Takahashi A, Okada E, Motegi SI, Amano H, Ishikawa O.
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Journal Title
Acta Derm Venereol.
Volume: 94
Issue: 4
Pages: 482-483
DOI
Related Report
Peer Reviewed
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