• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of regulatory B cell in the pathogenesis of systemic sclerosis

Research Project

Project/Area Number 25461686
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionKanazawa University

Principal Investigator

Matsushita Takashi  金沢大学, 大学病院, 講師 (60432126)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords全身性強皮症 / サイトカイン / 制御性B細胞 / 強皮症
Outline of Final Research Achievements

Sclerodermatous cGVHD (Scl-cGVHD) is characterized by fibrosis and autoimmune features resembling those of systemic sclerosis (SSc). Transplantation of B10.D2 bone marrow and splenocytes into irradiated-BALB/c mice is an established model of human Scl-cGVHD. To examine the role of regulatory B cells (Breg cell) in Scl-cGVHD, CD19-deficient (CD19-/-; lack of Breg cell) mice were used as donors or recipients in this model. CD19-/- donors induced more severe Scl-cGVHD than wild-type donors. Adoptive transfer of Breg cells attenuated the augmented manifestations of CD19-/- donor-induced Scl-cGVHD. The frequency of blood Breg cells was significantly lower in patients with SSc, and Breg cell levels inversely correlated with disease activity of SSc. These results suggest that decreased Breg cells contribute to the development of SSc.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 2 results) Presentation (2 results)

  • [Journal Article] Decreased Levels of Regulatory B cells in Patients with Systemic Sclerosis: Association with autoantibody production and disease activity.2016

    • Author(s)
      Matsushita T, Hamaguchi Y, Hasegawa M, Takehara K, Fujimoto M.
    • Journal Title

      Rheumatology (Oxford).

      Volume: 55 Issue: 2 Pages: 263-267

    • DOI

      10.1093/rheumatology/kev331

    • NAID

      120005764209

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Clinical and immunological predictors of scleroderma renal crisis in Japanese systemic sclerosis patients with anti-RNA polymerase III antibodies.2015

    • Author(s)
      Hamaguchi Y, Kodera M, Matsushita T, Usuda T, Kuwana M, Takehara K, and Fujimoto M
    • Journal Title

      Arthritis Rheumatol

      Volume: 67 Issue: 4 Pages: 1045-1052

    • DOI

      10.1002/art.38994

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] B cells promote tumor immunity against B16F10 melanoma.2014

    • Author(s)
      Kobayashi T, Hamaguchi Y, Hasegawa M, Fujimoto M, Takehara K, Matsushita T.
    • Journal Title

      Am J Pathol.

      Volume: 184 Issue: 11 Pages: 3120-3129

    • DOI

      10.1016/j.ajpath.2014.07.003

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regulatory B cells in mouse models of systemic lupus erythematosus (SLE).2014

    • Author(s)
      Matsushita T.
    • Journal Title

      Methods Mol Biol.

      Volume: 1190 Pages: 195-205

    • DOI

      10.1007/978-1-4939-1161-5_14

    • ISBN
      9781493911608, 9781493911615
    • Related Report
      2014 Research-status Report
  • [Journal Article] A crucial role of L-selectin in C protein-induced experimental polymyositis of mice.2014

    • Author(s)
      Oishi K, Hamaguchi Y, Matsushita T, Hasegawa M, Okiyama N, Dernedde J, Weinhart M, Haag R, Tedder TF, Takehara K, Kohsaka H, Fujimoto M.
    • Journal Title

      Arthritis Rheumatol.

      Volume: mar 18 Issue: 7 Pages: 1864-71

    • DOI

      10.1002/art.38630

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] FTY720 ameliorates murine Scl-cGVHD by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin2013

    • Author(s)
      Le Huu D, Matsushita T, Jin G, Hamaguchi Y, Hasegawa M, Takehara K, Fujimoto M
    • Journal Title

      Arthritis Rheum

      Volume: in press Issue: 6 Pages: 1624-35

    • DOI

      10.1002/art.37933

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Blockade of Syk Ameliorates the Development of Sclerodermatous Chronic Graft-Versus-Host Disease.2014

    • Author(s)
      Matsushita T, Le Huu D, Kimura H, Date M, Hamaguchi Y, Hasegawa M, Fujimoto M, Takehara K
    • Organizer
      ESDR 2014
    • Place of Presentation
      Copenhagen
    • Year and Date
      2014-09-11 – 2014-09-23
    • Related Report
      2014 Research-status Report
  • [Presentation] FTY720 ameliorates murine Scl-cGVHD by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into the skin.2013

    • Author(s)
      Matsushita T, Le Huu D, Takehara K, Fujimoto M
    • Organizer
      The American Association of Immunologists
    • Place of Presentation
      Honolulu, USA
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi