The roles and applications of IL-23 and IL-27 in new therapeutic strategies for malignant melanoma and psoriasis

Research Project

Project/Area Number	25461692
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Dermatology
Research Institution	Kobe University
Principal Investigator	NAGAI HIROSHI 神戸大学, 医学部附属病院, 講師 (80335447)
Co-Investigator(Kenkyū-buntansha)	YOSHIMOTO TAKAYUKI 東京医科大学, 医学部, 教授 (80202406)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	乾癬 / 悪性黒色腫
Outline of Final Research Achievements	We conducted studies on therapeutic effects of interleukin (IL)-27 on malignant melanoma and psoriasis in murine models. We demonstrated the mechanisms of synergistic antitumor effects induced by intratumoral CD4+ T lymphodepletion and OX40 agonist. We analyzed imiquimod-induced psoriasis-like dermatitis in IL-27 transgenic mice and WSX-1-deficient mice.

Report

(4 results)