The roles and applications of IL-23 and IL-27 in new therapeutic strategies for malignant melanoma and psoriasis
| Project/Area Number |
25461692
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kobe University |
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Principal Investigator |
NAGAI HIROSHI 神戸大学, 医学部附属病院, 講師 (80335447)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMOTO TAKAYUKI 東京医科大学, 医学部, 教授 (80202406)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 乾癬 / 悪性黒色腫 |
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| Outline of Final Research Achievements |
We conducted studies on therapeutic effects of interleukin (IL)-27 on malignant melanoma and psoriasis in murine models. We demonstrated the mechanisms of synergistic antitumor effects induced by intratumoral CD4+ T lymphodepletion and OX40 agonist. We analyzed imiquimod-induced psoriasis-like dermatitis in IL-27 transgenic mice and WSX-1-deficient mice.
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Report
(4 results)
Research Products
(3 results)
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[Journal Article] Intratumoral CD4+ T lymphodepletion sensitizes poorly immunogenic melanomas to immunotherapy with an OX40 agonist.2014
Author(s)
Fujiwara, S., Nagai, H., Shimoura, N., Oniki, S., Yoshimoto, T., and Nishigori, C.
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Journal Title
J. Invest. Dermatol.
Volume: 134
Issue: 7
Pages: 1884-1892
DOI
Related Report
Peer Reviewed
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