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Study for a mechanism of prolonged CD203c expression-based basophil activation in the patients with red meat allergy

Research Project

Project/Area Number 25461693
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionShimane University

Principal Investigator

Chinuki Yuko  島根大学, 医学部, 講師 (00294380)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords獣肉アレルギー / マダニ咬傷 / 好塩基球 / CD203c発現定量 / α-Gal / 好塩基球活性化マーカーCD203c / 牛肉アレルギー / α-gal / マダニ / 血液型 / 糖鎖 / 好塩基球活性化試験 / カレイ魚卵 / セツキシマブ
Outline of Final Research Achievements

We found that patients with red meat allergy showed prolonged CD203c expression-based basophil activation even if they did not developed allergic reaction. The incidence of red meat allergy is high in Shimane prefecture, as is tick-transmitted Japanese spotted fever. Therefore, we speculated that tick bites may cause these meat allergies. The carbohydrate α-Gal was detected in the salivary gland protein of Haemaphysalis longicornis (H. longicornis), the vector for Japanese spotted fever, by immunoblotting using anti-α-Gal antibody. H. longicornis salivary gland protein-specific IgE was detected in the sera of 24 of 30 patients with red meat allergies. Sensitization to tick salivary gland protein containing α-Gal is possibly a major role in the prolonged CD203c expression-based basophil activation in the patients with red meat allergy.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (18 results)

All 2016 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (12 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results) Book (1 results)

  • [Journal Article] Haemaphysalis longicornis tick bites are a possible cause of red meat allergy in Japan.2016

    • Author(s)
      Chinuki Y, Ishiwata K, Yamaji K, Takahashi H, Morita E.
    • Journal Title

      Allergy

      Volume: 71 Issue: 3 Pages: 421-425

    • DOI

      10.1111/all.12804

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Laminin γ-1 and collagen α-1 (VI) chain are galactose-α-1,3-galactose–bound allergens in beef.2014

    • Author(s)
      Takahashi H, Chinuki Y, et al.
    • Journal Title

      Allergy

      Volume: 69 Pages: 199-207

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] セツキシマブによるアナフィラキシーの予知予防.2014

    • Author(s)
      千貫祐子,伊藤和行,高橋 仁,森田栄伸.
    • Journal Title

      日本皮膚科学会雑誌

      Volume: 124 Pages: 3090-3092

    • Related Report
      2014 Research-status Report
  • [Journal Article] セツキシマブによるアナフィラキシーショックの4例2014

    • Author(s)
      千貫祐子、伊藤和行、武田真紀子、他
    • Journal Title

      日本皮膚科学会雑誌

      Volume: 124 Pages: 179-183

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 牛肉アレルギー患者20例の臨床的および血清学的解析2013

    • Author(s)
      千貫祐子、高橋 仁、森田栄伸
    • Journal Title

      日本皮膚科学会雑誌

      Volume: 123 Pages: 1807-1814

    • NAID

      130004702090

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 本邦における獣肉アレルギーの解析~α-Gal storyとPork-cat syndrome~2015

    • Author(s)
      千貫祐子,森田栄伸
    • Organizer
      日本皮膚科学会第143回宮崎地方会
    • Place of Presentation
      宮崎観光ホテル(宮崎県)
    • Year and Date
      2015-11-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Red Meat Allergy and Its Clinical Diversity2015

    • Author(s)
      Yuko Chinuki, Eishin Morita
    • Organizer
      The 23RD World Congress of Dermatology
    • Place of Presentation
      Vancouver, CANADA.
    • Year and Date
      2015-06-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 頭頸部癌患者90名におけるα-gal関連抗原特異的IgEの検索とセツキシマブによるアナフィラキシー回避の試み2015

    • Author(s)
      千貫祐子,伊藤和行,高橋 仁,森田栄伸
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] セツキシマブ投与時のアナフィラキシーショックによる死亡例の解析2015

    • Author(s)
      千貫祐子,鵜沼香奈,森田栄伸
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 頭頸部癌患者64名におけるα-Gal関連抗原特異的IgE保有率とセツキシマブによるアナフィラキシー回避の試み.2014

    • Author(s)
      千貫祐子,伊藤和行,ほか.
    • Organizer
      第66回日本皮膚科学会西部支部学術大会
    • Place of Presentation
      アルファあなぶきホール(高松市)
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Research-status Report
  • [Presentation] 獣肉アレルギー30例の発症原因と血液型の関与,交差反応性に関する解析.2014

    • Author(s)
      千貫祐子,石渡賢治,高橋 仁,森田栄伸.
    • Organizer
      第26回日本アレルギー学会春季臨床大会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2014-05-09 – 2014-05-11
    • Related Report
      2014 Research-status Report
  • [Presentation] Galactose-α-1,3-galactose(α-gal)-specific IgE test is highly useful for predicting Cetuximab-induced Anaphylaxis.2014

    • Author(s)
      Morita E, Chinuki Y, et al.
    • Organizer
      6th Drug Hypersensitivity Meeting.
    • Place of Presentation
      Switzerland
    • Year and Date
      2014-04-09 – 2014-04-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 牛肉アレルギー発症におけるマダニ咬傷の関与2013

    • Author(s)
      千貫祐子、石渡賢治、高橋 仁、森田栄伸
    • Organizer
      第25回日本アレルギー学会春季臨床大会
    • Place of Presentation
      (横浜市)パシフィコ横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 食物アレルギーに対する低アレルゲン食とオマリズマブの試み2013

    • Author(s)
      千貫祐子、森田栄伸
    • Organizer
      第112回日本皮膚科学会総会
    • Place of Presentation
      (横浜市)パシフィコ横浜
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 抗EGFR抗体製剤による副作用-多様なアレルギー反応2013

    • Author(s)
      千貫祐子、森田栄伸
    • Organizer
      第112回日本皮膚科学会総会
    • Place of Presentation
      (横浜市)パシフィコ横浜
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 牛肉アレルギー患者28例の発症原因と交差反応に関する検討2013

    • Author(s)
      千貫祐子、石渡賢治、高橋 仁、森田栄伸
    • Organizer
      第77回日本皮膚科学会東部支部学術大会
    • Place of Presentation
      (大宮市)大宮ソニックシティ
    • Related Report
      2013 Research-status Report
  • [Presentation] 食物アレルギーの新規診断法2013

    • Author(s)
      千貫祐子
    • Organizer
      第65回日本皮膚科学会西部支部学術大会
    • Place of Presentation
      (鹿児島市)かごしま県民交流センター
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 年代別食物アレルギーのすべて2013

    • Author(s)
      千貫祐子
    • Total Pages
      264
    • Publisher
      南山堂(東京都)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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